Head and neck squamous cell cancers in the United States are rare and the risk now is higher among white individuals compared with black individuals.
Head and neck squamous cell cancers in the United States are rare and the risk now is higher among white individuals compared with black individuals.
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DOI：
10.1002/cncr.31322
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发表时间：
2018-05-15
期刊：
影响因子：
6.2
通讯作者：
D'Souza G
中科院分区：
文献类型：
--
作者：
Fakhry C;Krapcho M;Eisele DW;D'Souza G
口咽鳞状细胞癌(OPSCC)发病率的增加是有目共睹的。然而，美国头颈部鳞状细胞癌(HNSCC)总体上包括主要解剖部位和按性别、种族和年龄划分的非口咽(Non-OP)HNSCC的最新发病率估计和趋势并未得到很好的描述。使用监测、流行病学和最终结果(SEER)数据库对1992-2014年间发生的HNSCC进行回顾性分析，以评估总体HNSCC、OPSCC和非OP HNSCC(喉、口腔、下咽、鼻咽、鼻腔)的发病率。计算总体和感兴趣亚组的发病率，并使用发病率比(IRR)比较不同组之间的发病率。报告的发病率为每10万人，年龄调整为2000年美国标准人口(19个年龄组--人口普查P25-1130)。有和没有连接点的年度百分比变化(APC)模拟了HNSCC的发病率总体下降(平均APC-0.8p<；0.001)，尽管OPSCC的发病率显著增加，最显著的是在2000年至2014年(APC=2.1p<；0.001)。事实上，所有非手术部位的女性和男性的HNSCC的发病率都有显著的下降(P<；0.001)。在女性中，口腔鳞状细胞癌的风险也显著降低(APC0.8，p=0.002)，而在男性中，口腔鳞癌的风险在1992年至2001年期间保持稳定(APC0.4，p=0.42)，然后在2001年至2014年间显著增加(APC2.7，p<；0.001)。黑人女性(AAPC-2.6P<；0.001)和男性(AAPC-3.0P<；0.001)的非OP HNSCC风险下降尤其明显。虽然HNSCC的发病率过去在黑人中最高，但自2009年以来，白人的HNSCC发病率高于黑人。HNSCC的发病率正在下降，尤其是在非OP HNSCC和黑人中。
The increasing incidence of oropharynx squamous cell cancer (OPSCC) is well established. However, up-to date incidence estimates and trends for head and neck squamous cell cancers (HNSCC) overall including major anatomic sites and non-oropharyngeal (non-OP) HNSCCs by sex, race and age in the United States (US) are not well described. Retrospective analysis of incident HNSCCs during 1992-2014 using Surveillance, Epidemiology, and End Results (SEER) database was used to evaluate incidence of HNSCCs overall, OPSCC and non-OP HNSCC (larynx, oral cavity, hypopharynx, nasopharynx, nasal cavity). Incidence rates were calculated overall and by subgroups of interest, and incidence rate ratios (IRR) were used to compare rates between groups. The incidence rates presented are per 100,000 people and age-adjusted to the 2000 US Standard Population (19 age groups – Census P25-1130). Annual percent change (APC) was modeled with and without joinpoints Incidence of HNSCC overall declined (average APC [aAPC] -0.8, p<0.001) in spite of significant increases in incidence of OPSCCs, most notably between 2000-2014 (APC=2.1, p<0.001). Indeed, significant declines in incidence were observed for all non-OP HNSCC sites, for both women and men (each p<0.001). Among women, risk of OPSCC also significantly decreased (aAPC -0.8, p=0.002), while among men OPSCC risk was stable during 1992-2001 (APC 0.4, p=0.42), then significantly increased during 2001-2014 (APC 2.7, p<0.001). Decreases in non-OP HNSCC risk were especially large for Black women (aAPC -2.6, p<0.001) and men (aAPC -3.0, p<0.001). While incidence of HNSCC used to be highest among Blacks, since 2009 HNSCC incidence is higher among Whites than Blacks. Incidence of HNSCC is declining, especially for non-OP HNSCC and Blacks.
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影响因子：
45.3
作者：
Patel, Sagar C.;Carpenter, William R.;Chera, Bhishamjit S.
通讯作者：
Chera, Bhishamjit S.
影响因子：
4.8
作者：
Tota, Joseph E.;Anderson, William F.;Chaturvedi, Anil K.
通讯作者：
Chaturvedi, Anil K.
影响因子：
28.4
作者：
D'Souza G;Westra WH;Wang SJ;van Zante A;Wentz A;Kluz N;Rettig E;Ryan WR;Ha PK;Kang H;Bishop J;Quon H;Kiess AP;Richmon JD;Eisele DW;Fakhry C
通讯作者：
Fakhry C
性别，种族和人乳头瘤病毒在口咽和非咽脑颈部和颈部鳞状细胞癌中的预后作用。
影响因子：
6.2
作者：
Fakhry C;Westra WH;Wang SJ;van Zante A;Zhang Y;Rettig E;Yin LX;Ryan WR;Ha PK;Wentz A;Koch W;Richmon JD;Eisele DW;D'Souza G
通讯作者：
D'Souza G
影响因子：
6.2
作者：
Patel, Mira A.;Blackford, Amanda L.;Fakhry, Carole
通讯作者：
Fakhry, Carole