8q24 risk alleles in West African and Caribbean men.
8q24 risk alleles in West African and Caribbean men.
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DOI：
10.1002/pros.22486
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发表时间：
2012-09-01
期刊：
影响因子：
2.8
通讯作者：
Kittles, Rick A.
中科院分区：
文献类型：
--
作者：
Murphy, Adam B.;Ukoli, Flora;Freeman, Vincent;Bennett, Frankly;Aiken, William;Tulloch, Trevor;Coard, Kathleen;Angwafo, Fru;Kittles, Rick A.
多项遗传学研究证实，8q24变异与前列腺癌(CAP)易感性有关。然而，生活在西非的男性所面临的风险到底有多大还不得而知。在这里，我们确定了8q24风险等位基因的流行率，并测试了来自尼日利亚农村、喀麦隆和加勒比海岛国牙买加的西非后裔人群中与CAP风险等位基因的相关性。在经组织学证实的CAP病例(n=308)和临床评估的对照组(n=469)中，对10个8q24 SNPs进行了基因分型。此外，对来自塞拉利昂(n=380)的无关个体进行了基因分型，以比较等位基因频率比较。在西非人群中，rs6983561、rs7008482和rs16901979三个单核苷酸多态与肺炎风险显著相关(P<；0.03)。在我们的加勒比海样本中没有观察到与CAP有关的情况。Rs6983267、rs7008482和rs7000448的风险等位基因在西非非常普遍(>；84%)。我们还发现，在3个西非民族的1,886条染色体上未发现非洲特有的SNP bd11934905的A风险等位基因，这表明该等位基因可能在整个西非并不常见，但在地理上仅限于特定的民族(S)。我们提供了尼日利亚和喀麦隆男性中8q24 SNPs与前列腺癌风险相关的证据。我们的研究首次揭示了8q24变异(特别是第2区)在两个西非国家内存在的遗传风险。最重要的是，考虑到非裔美国人CAP的不同负担，我们的发现支持需要在西非裔人群中进行更大规模的基因研究，以验证和识别8q24区域易感基因的功能。
Multiple genetic studies have confirmed associations of 8q24 variants with susceptibility to prostate cancer (CaP). However, the magnitude of risk conferred in men living in west Africa is unknown. Here we determine the prevalence of 8q24 risk alleles and test for association with CaP risk alleles in west African descent populations from rural Nigeria, Cameroon, and the Caribbean island of Jamaica. Ten 8q24 SNPs were genotyped in histologically-confirmed CaP cases (n=308) and clinically evaluated controls (n=469). In addition, unrelated individuals from Sierra Leone (n=380) were genotyped for comparison of allele frequency comparisons. SNPs rs6983561, rs7008482, and rs16901979 were significantly associated with CaP risk in west Africans (P<0.03). No associations with CaP were observed in our Caribbean samples. Risk alleles for rs6983267, rs7008482, and rs7000448 were highly prevalent (>84%) in West Africa. We also reveal that the A-risk allele for the ‘African-specific’ SNP bd11934905 was not observed in 1,886 chromosomes from three west African ethnic groups suggesting that this allele may not be common across west Africa, but is geographically restricted to specific ethnic group(s). We provide evidence of association of 8q24 SNPs with prostate cancer risk in men from Nigeria and Cameroon. Our study is the first to reveal genetic risk due to 8q24 variants (in particular, region 2) with CaP within two west Africa countries. Most importantly, in light of the disparate burden of CaP in African Americans, our findings support the need for larger genetic studies in west African descent populations to validate and discern function of susceptibility loci in the 8q24 region.
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影响因子：
2.8
作者：
Okobia, Michael N.;Zmuda, Joseph M.;Ferrell, Robert E.;Patrick, Alan L.;Bunker, Clareann H.
通讯作者：
Bunker, Clareann H.
影响因子：
30.8
作者：
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影响因子：
11.2
作者：
Poynter, Jenny N.;Figueiredo, Jane C.;Le Marchand, Loic
通讯作者：
Le Marchand, Loic
影响因子：
3.8
作者：
Benford ML;VanCleave TT;Lavender NA;Kittles RA;Kidd LR
通讯作者：
Kidd LR
影响因子：
5.3
作者：
Potts, PR;Yu, HT
通讯作者：
Yu, HT