Preventing Olfactory Deterioration: Olfactory Training May Be of Help in Older People
Preventing Olfactory Deterioration: Olfactory Training May Be of Help in Older People
复制标题
防止嗅觉退化：嗅觉训练可能对老年人有帮助
DOI：
--
复制
发表时间：
2014
影响因子：
6.3
通讯作者：
T. Hummel
中科院分区：
文献类型：
--
作者：
V. Schriever;S. Lehmann;Judith Prange;T. Hummel
尽管 ChEI 可能会导致外周胆碱能不良事件，但这项基于人群的大型研究发现 ChEI 的使用与老年人上消化道出血之间没有显着关联。 ChEI 与上消化道出血之间缺乏显着关联可能是因为 ChEI 引起的胃肠道不良事件通常是短暂的，并且会随着药物的持续使用而减少。这项研究有潜在的局限性。首先，管理数据库的使用妨碍了捕获临床重要信息的能力，例如疾病严重程度和胃肠道病理学。其次，考虑到接受卡巴拉汀或加兰他敏治疗的受试者比例较小，个别 ChEI 对上消化道出血的影响与非使用者群体相比无法进行有意义的比较。未来的研究需要估计长期使用 ChEI 的人和高危个体（例如居住在长期护理院或有上消化道出血史的人）的上消化道出血发生率。
Although it is plausible that ChEIs may result in peripheral cholinergic adverse events, this large population-based study found no significant association between ChEI use and upper GI bleeding in elderly adults. Lack of a significant association between ChEIs and upper GI bleeding may be because adverse GI events resulting from ChEIs are typically transient and decrease with continued use of the drugs. This study has potential limitations. First, use of administrative databases precludes the ability to capture clinically important information such as disease severity and GI pathology. Second, given the small proportion of the subjects who received rivastigmine or galantamine, the effect of individual ChEIs on upper GI bleeding could not be meaningfully compared with that of the nonuser cohort. Future research is needed to estimate the incidence of upper GI bleeding in chronic users of ChEIs and in high-risk individuals, such as those living in long-term care residences or with a history of upper GI hemorrhage.
影响因子：
120.7
作者：
Murphy, C;Schubert, CR;Nondahl, DM
通讯作者：
Nondahl, DM
影响因子：
--
作者：
Santos, DV;Reiter, ER;Costanzo, RM
通讯作者：
Costanzo, RM
DOI：
10.1001/jama.1997.03550160077042
发表时间：
1997-10
期刊：
JAMA
影响因子：
--
作者：
S. Schiffman
通讯作者：
S. Schiffman