GAG content, fiber stiffness, and fiber angle affect swelling-based residual stress in the intact annulus fibrosus
GAG content, fiber stiffness, and fiber angle affect swelling-based residual stress in the intact annulus fibrosus
复制标题
GAG 含量、纤维刚度和纤维角度影响完整纤维环中基于膨胀的残余应力
DOI：
10.1007/s10237-018-1105-9
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发表时间：
2019
影响因子：
3.5
通讯作者：
O’Connell, Grace D.
中科院分区：
文献类型：
--
作者：
Yang, Bo;O’Connell, Grace D.
具有高糖胺聚糖（GAG）含量的生物组织具有通过从周围环境吸收水分子而膨胀的优异能力。我们最近的工作表明，各向异性的组织肿胀取决于纤维网络结构，包括纤维角度，纤维刚度，和层状结构。然而，这项工作并没有评估原位边界条件的影响，如肾豆形状的纤维环（AF），对溶胀行为。完整AF的生化组成在GAG组成、胶原纤维角度和纤维硬度方面是不均匀的。此外，内AF中的GAG含量随着变性而显著降低。在这项研究中，我们研究了GAG含量的作用，纤维角度，纤维刚度AF肿胀和残余应变的发展，使用有限元模型的基础上，人类腰椎间盘。我们的研究结果表明，环形环结构有很大的影响，通过发展区域依赖性的压缩应力/拉伸在内层和拉伸应力/拉伸在外部AF的肿胀。肿胀为基础的残余拉伸与实验测量值相媲美，这表明组织肿胀在维持残余应力的重要作用。此外，如观察到的变性，内部AF中的GAG损失使周向应力降低超过65%。纤维角度和刚度的均匀分布高估或低估了AF溶胀行为，如溶胀比、周向/轴向拉伸和纤维拉伸/重定向。这些发现表明，需要在有限元模型中包括天然纤维结构，以准确预测组织失效，以及培养工程化椎间盘。
Biological tissues with a high glycosaminoglycan (GAG) content have an excellent ability to swell by absorbing water molecules from the surrounding environment. Our recent work showed that anisotropy in tissue swelling depends on the fiber-network architecture, including fiber angle, fiber stiffness, and lamellae structure. However, that work did not evaluate the effect of in situ boundary conditions, such as the kidney-bean shape of the annulus fibrosus (AF), on swelling behavior. The biochemical composition of intact AF is inhomogeneous with respect to GAG composition, collagen fiber angle, and fiber stiffness. Moreover, the GAG content in the inner AF decreases significantly with degeneration. In this study, we investigated the role of GAG content, fiber angle, and fiber stiffness in AF swelling and residual strain development using a finite element model based on a human lumbar disk. Our results showed that the annular ring structure had a great impact on swelling by developing region-dependent compressive stress/stretch in the inner layers and tensile stress/stretch in the outer AF. Swelling-based residual stretch was comparable to experimentally measured values, suggesting an important role of tissue swelling in maintaining residual stresses. Moreover, GAG loss in the inner AF, as observed with degeneration, decreased circumferential-direction stress by over 65%. Homogeneous distributions of fiber angle and stiffness overestimated or underestimated AF swelling behavior, such as swelling ratio, circumferential/axial stretch, and fiber stretch/reorientation. These findings demonstrate the need to include native fiber architecture in finite element models, to accurately predict tissue failure, as well as to cultivate engineered disks.
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影响因子：
2.4
作者：
Ateshian, GA;Chahine, NO;Hung, CT
通讯作者：
Hung, CT
生物医学材料机械行为杂志纤维增强软组织的膨胀受到纤维取向、纤维刚度和片层结构的影响
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
D. McMillan;G. Garbutt;M A Adams
通讯作者：
M A Adams
影响因子：
2.4
作者：
Jacobs, Nathan T.;Cortes, Daniel H.;Peloquin, John M.;Vresilovic, Edward J.;Elliott, Dawn M.
通讯作者：
Elliott, Dawn M.
影响因子：
4.1
作者：
Bowles, Robby D.;Williams, Rebecca M.;Bonassar, Lawrence J.
通讯作者：
Bonassar, Lawrence J.
影响因子：
2.4
作者：
Guerin, Heather Anne L.;Elliott, Dawn M.
通讯作者：
Elliott, Dawn M.