Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort.
Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort.
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DOI：
10.1007/s10067-015-2941-y
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发表时间：
2015-07
影响因子：
3.4
通讯作者：
Brown, Elizabeth E.
中科院分区：
文献类型：
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作者：
Arroyo-Avila, Mariangeli;Santiago-Casas, Yesenia;McGwin, Gerald, Jr.;Cantor, Ryan S.;Petri, Michelle;Ramsey-Goldman, Rosalind;Reveille, John D.;Kimberly, Robert P.;Alarcon, Graciela S.;Vila, Luis M.;Brown, Elizabeth E.
这项研究的目的是在一个大型的多民族SLE队列中确定抗Sm抗体与临床表现、合并症和疾病损害的相关性。来自美国纵向队列的系统性红斑狼疮患者(根据美国风湿病学会的标准)，年龄≥16岁，登记时疾病持续时间≤10年，以及确定的种族(非裔美国人、西班牙裔或高加索人)。确定社会经济学人口学特征、累积临床表现、合并症和疾病损害(根据系统性红斑狼疮国际协作诊所损害指数[SDI])。通过对年龄、性别、种族、病程、教育程度、医疗保险和吸烟进行调整的多变量Logistic回归分析，检验抗Sm抗体与临床特征的相关性。共对2322例SLE患者进行了研究。平均发病年龄(标准差，SD)为34.4(12.8)岁，平均病程(SD)为9.0(7.9)年，其中女性2127例(91.6%)。抗Sm抗体阳性579例(24.9%)。在多变量分析中，抗Sm抗体与浆膜炎、肾脏受累、精神病、血管炎、雷诺现象、溶血性贫血、白细胞减少、淋巴细胞减少和动脉高血压显著相关。没有发现与损害累积有显著关联。在这组SLE患者中，抗Sm抗体与几个临床特征有关，包括严重的表现，如肾脏、神经和血液系统疾病以及血管炎。
The aim of this study was to determine the association of anti-Sm antibodies with clinical manifestations, comorbidities, and disease damage in a large multi-ethnic SLE cohort. SLE patients (per American College of Rheumatology criteria), age ≥16 years, disease duration ≤10 years at enrollment, and defined ethnicity (African American, Hispanic or Caucasian), from a longitudinal US cohort were studied. Socioeconomic-demographic features, cumulative clinical manifestations, comorbidities, and disease damage (as per the Systemic Lupus International Collaborating Clinics Damage Index [SDI]) were determined. The association of anti-Sm antibodies with clinical features was examined using multivariable logistic regression analyses adjusting for age, gender, ethnicity, disease duration, level of education, health insurance, and smoking. A total of 2322 SLE patients were studied. The mean (standard deviation, SD) age at diagnosis was 34.4 (12.8) years and the mean (SD) disease duration was 9.0(7.9)years; 2127 (91.6 %) were women. Anti-Sm antibodies were present in 579 (24.9 %) patients. In the multivariable analysis, anti-Sm antibodies were significantly associated with serositis, renal involvement, psychosis, vasculitis, Raynaud's phenomenon, hemolytic anemia, leukopenia, lymphopenia, and arterial hypertension. No significant association was found for damage accrual. In this cohort of SLE patients, anti-Sm antibodies were associated with several clinical features including serious manifestations such as renal, neurologic, and hematologic disorders as well as vasculitis.
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影响因子：
4.1
作者：
Li J;Leng X;Li Z;Ye Z;Li C;Li X;Zhu P;Wang Z;Zheng Y;Li X;Zhang M;Tian XP;Li M;Zhao J;Zhang FC;Zhao Y;Zeng X
通讯作者：
Zeng X
影响因子：
2.6
作者：
Ippolito, A.;Wallace, D. J.;Petri, M.
通讯作者：
Petri, M.
影响因子：
27.4
作者：
BOEY, ML;PEEBLES, CL;TAN, EM
通讯作者：
TAN, EM
影响因子：
3.9
作者：
Artim-Esen, Bahar;Cene, Erhan;Inanc, Murat
通讯作者：
Inanc, Murat
影响因子：
--
作者：
BARADA, FA;ANDREWS, BS;TAYLOR, RP
通讯作者：
TAYLOR, RP