Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking.
Molecular and Circuit-Dynamical Identification of Top-Down Neural Mechanisms for Restraint of Reward Seeking.
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DOI：
10.1016/j.cell.2017.07.020
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发表时间：
2017-08-24
期刊：
影响因子：
64.5
通讯作者：
Deisseroth K
中科院分区：
文献类型：
--
作者：
Kim CK;Ye L;Jennings JH;Pichamoorthy N;Tang DD;Yoo AW;Ramakrishnan C;Deisseroth K
寻求奖励的行为是生存的基础，但抑制这种行为也是必不可少的，即使是高价值的奖励。在人类和啮齿类动物中，内侧前额叶皮层（mPFC）与抑制奖赏寻求有关;然而，尽管mPFC在健康和疾病中具有重要意义，但其调节奖赏寻求的神经回路仍不完全清楚。在这里，我们表明，一个特定的子集的表面mPFC预测的一个子场的核丘脑（NAc）神经元自然编码的决定，启动或抑制奖励寻求面临惩罚的风险时。这些自上而下的投射神经元的高分辨率亚群，通过双光子Ca 2+成像和活性依赖性标记来招募相关神经元，被发现能够抑制奖励寻求。这种天然活性分辨的mPFC至NAc投射显示出独特的分子遗传学和微电路水平特征，与奖赏寻求行为调节中的保守作用一致，提供了行为和可能的治疗意义的细胞和解剖学标识符。
Reward-seeking behavior is fundamental to survival, but suppression of this behavior can be essential as well, even for rewards of high value. In humans and rodents, the medial prefrontal cortex (mPFC) has been implicated in suppressing reward seeking; however, despite vital significance in health and disease, the neural circuitry through which mPFC regulates reward seeking remains incompletely understood. Here, we show that a specific subset of superficial mPFC projections to a subfield of nucleus accumbens (NAc) neurons naturally encodes the decision to initiate or suppress reward seeking when faced with risk of punishment. A highly resolved subpopulation of these top-down projecting neurons, identified by 2-photon Ca2+ imaging and activity-dependent labeling to recruit the relevant neurons, was found capable of suppressing reward seeking. This natural activity-resolved mPFC-to-NAc projection displayed unique molecular-genetic and microcircuit-level features concordant with a conserved role in the regulation of reward-seeking behavior, providing cellular and anatomical identifiers of behavioral and possible therapeutic significance.
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影响因子：
48
作者：
Kim CK;Yang SJ;Pichamoorthy N;Young NP;Kauvar I;Jennings JH;Lerner TN;Berndt A;Lee SY;Ramakrishnan C;Davidson TJ;Inoue M;Bito H;Deisseroth K
通讯作者：
Deisseroth K
影响因子：
16.2
作者：
Kim EJ;Juavinett AL;Kyubwa EM;Jacobs MW;Callaway EM
通讯作者：
Callaway EM
影响因子：
64.8
作者：
Cui, Guohong;Jun, Sang Beom;Jin, Xin;Pham, Michael D.;Vogel, Steven S.;Lovinger, David M.;Costa, Rui M.
通讯作者：
Costa, Rui M.
DOI：
10.1073/pnas.0603081103
发表时间：
2006-06-06
影响因子：
11.1
作者：
Hnasko, Thomas S.;Perez, Francisco A.;Palmiter, Richard D.
通讯作者：
Palmiter, Richard D.
影响因子：
1.9
作者：
Jonkman, Sietse;Mar, Adam C.;Everitt, Barry J.
通讯作者：
Everitt, Barry J.