SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry.
SynthSR: A public AI tool to turn heterogeneous clinical brain scans into high-resolution T1-weighted images for 3D morphometry.
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DOI：
10.1126/sciadv.add3607
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发表时间：
2023-02-03
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影响因子：
13.6
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中科院分区：
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每年，世界各地的医院都会采集数百万张脑部磁共振成像 (MRI) 扫描结果。这些有可能彻底改变我们对许多神经系统疾病的理解，但由于其各向异性分辨率，其形态测量分析尚未成为可能。我们提出了一种人工智能技术“SynthSR”，它采用任何 MR 对比度（T1、T2 等）、方向（轴向/冠状/矢状）和分辨率进行临床脑部 MRI 扫描，并将其转换为几乎所有现有人类神经成像工具都可以使用的高分辨率 T1 扫描。我们展示了对对照以及患有脑肿瘤、中风和阿尔茨海默病的患者进行超过 10,000 次扫描的分割、配准和图谱分析的结果。 SynthSR 产生的形态测量结果与高分辨率 T1 扫描获得的结果高度相关。 SynthSR 允许的样本量有可能克服前瞻性研究的功率限制，并为健康和患病的人类大脑提供新的线索。公共人工智能工具可将任何分辨率/对比度的临床脑部 MRI 转换为与神经影像管道兼容的 1mm T1 扫描。
Every year, millions of brain magnetic resonance imaging (MRI) scans are acquired in hospitals across the world. These have the potential to revolutionize our understanding of many neurological diseases, but their morphometric analysis has not yet been possible due to their anisotropic resolution. We present an artificial intelligence technique, “SynthSR,” that takes clinical brain MRI scans with any MR contrast (T1, T2, etc.), orientation (axial/coronal/sagittal), and resolution and turns them into high-resolution T1 scans that are usable by virtually all existing human neuroimaging tools. We present results on segmentation, registration, and atlasing of >10,000 scans of controls and patients with brain tumors, strokes, and Alzheimer’s disease. SynthSR yields morphometric results that are very highly correlated with what one would have obtained with high-resolution T1 scans. SynthSR allows sample sizes that have the potential to overcome the power limitations of prospective research studies and shed new light on the healthy and diseased human brain. A public AI tool turns clinical brain MRI of any resolution/contrast into 1mm T1 scans compatible with neuroimaging pipelines.
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影响因子：
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影响因子：
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