A distal centriolar protein network controls organelle maturation and asymmetry.
A distal centriolar protein network controls organelle maturation and asymmetry.
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DOI：
10.1038/s41467-018-06286-y
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发表时间：
2018-09-26
影响因子：
16.6
通讯作者：
Dynlacht BD
中科院分区：
文献类型：
--
作者：
Wang L;Failler M;Fu W;Dynlacht BD
A long-standing mystery in the centrosome field pertains to the origin of asymmetry within the organelle. The removal of daughter centriole-specific/enriched proteins (DCPs) and acquisition of distal appendages on the future mother centriole are two important steps in the generation of asymmetry. We find that DCPs are recruited sequentially, and their removal is abolished in cells lacking Talpid3 or C2CD3. We show that removal of certain DCPs constitutes another level of control for distal appendage (DA) assembly. Remarkably, we also find that Talpid3 forms a distal centriolar multi-functional hub that coordinates the removal of specific DCPs, DA assembly, and recruitment of ciliary vesicles through distinct regions mutated in ciliopathies. Finally, we show that Talpid3, C2CD3, and OFD1 differentially regulate the assembly of sub-distal appendages, the CEP350/FOP/CEP19 module, centriolar satellites, and actin networks. Our work extends the spatial and functional understanding of proteins that control organelle maturation and asymmetry, ciliogenesis, and human disease. Removal of daughter centriole-specific/enriched proteins (DCPs) and assembly of distal appendages (DA) are important for centrosome asymmetry. Here, the authors report that a centriolar distal end protein network regulates DCP removal, DA assembly, and ciliary vesicle docking.
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影响因子：
11.8
作者：
Antoniades, Ioanna;Stylianou, Panayiota;Skourides, Paris A.
通讯作者：
Skourides, Paris A.
DOI：
10.1242/dev.029835
发表时间：
2008-12
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Hoover AN;Wynkoop A;Zeng H;Jia J;Niswander LA;Liu A
通讯作者：
Liu A
影响因子：
21.3
作者：
Lawo, Steffen;Hasegan, Monica;Pelletier, Laurence
通讯作者：
Pelletier, Laurence
影响因子：
3.3
作者：
Guarguaglini, G;Duncan, PI;Nigg, EA
通讯作者：
Nigg, EA
影响因子：
7.7
作者：
Li, Ji;Kim, Sehyun;Dynlacht, Brian D.
通讯作者：
Dynlacht, Brian D.