High rate of A(H1N1)pdm09 infections among rural Thai villagers, 2009-2010.
High rate of A(H1N1)pdm09 infections among rural Thai villagers, 2009-2010.
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DOI：
10.1371/journal.pone.0106751
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Gray GC
中科院分区：
文献类型：
--
作者：
Khuntirat B;Yoon IK;Chittaganpitch M;Krueger WS;Supawat K;Blair PJ;Putnam SD;Gibbons RV;Buddhari D;Sawanpanyalert P;Heil GL;Friary JA;Gray GC
甲型H1N1大流行性流感pdm09于2009年在泰国出现。一项流感样疾病（ILI）的前瞻性纵向成人队列和家庭传播研究正在泰国农村地区进行。评估队列和家庭成员的症状和亚临床A(H1N1)pdm09感染率。在2008-2010年期间，对800名泰国成年人进行了积极的基于社区的ILI监测。采用qRT-PCR对急性呼吸道感染病例样本进行A(H1N1)pdm09检测；采用A(H1N1)pdm09血凝抑制试验（HI）检测急性期和恢复期60天血样。对入组、12个月和24个月随访的血液样本进行HI检测A(H1N1)pdm09血清转化。将患有ILI的甲型流感感染队列受试者的家庭成员纳入家庭传播调查，并对第0天和第60天的血液样本和急性呼吸道样本进行qRT-PCR或HI检测A(H1N1)pdm09。无A(H1N1)pdm09阳性ILI的年度血液样本血清转换被认为是亚临床感染。2009/2010年队列中A(H1N1)pdm09感染的2年累积发病率为10.8%(84/781)，2009年的年发病率为1.2%，2010年为9.7%；亚临床感染占83.3%（2009年为50%，2010年为85.9%）。出生≤1957年的成年人2年累积发病率最低（5%）。家庭接触者中甲型H1N1流感pdm09继发率为47.2% (17/36)；其中47.1%为亚临床感染。家庭接触者中A(H1N1)pdm09继发发病率最高的是1990 - 2003年出生的儿童（70.6%,12/17）。泰国成人的亚临床A(H1N1)pdm09感染频繁发生，在所有A(H1N1)pdm09感染中所占的比例比以前估计的要大。亚临床感染在甲型H1N1流感病毒pdm09传播中的作用对制定预测和预防甲型H1N1流感病毒和其他流感病毒株传播的策略具有重要意义。
Pandemic influenza A(H1N1)pdm09 emerged in Thailand in 2009. A prospective longitudinal adult cohort and household transmission study of influenza-like illness (ILI) was ongoing in rural Thailand at the time of emergence. Symptomatic and subclinical A(H1N1)pdm09 infection rates in the cohort and among household members were evaluated. A cohort of 800 Thai adults underwent active community-based surveillance for ILI from 2008–2010. Acute respiratory samples from ILI episodes were tested for A(H1N1)pdm09 by qRT-PCR; acute and 60-day convalescent blood samples were tested by A(H1N1)pdm09 hemagglutination inhibition assay (HI). Enrollment, 12-month and 24-month follow-up blood samples were tested for A(H1N1)pdm09 seroconversion by HI. Household members of influenza A-infected cohort subjects with ILI were enrolled in household transmission investigations in which day 0 and 60 blood samples and acute respiratory samples were tested by either qRT-PCR or HI for A(H1N1)pdm09. Seroconversion between annual blood samples without A(H1N1)pdm09-positive ILI was considered as subclinical infection. The 2-yr cumulative incidence of A(H1N1)pdm09 infection in the cohort in 2009/2010 was 10.8% (84/781) with an annual incidence of 1.2% in 2009 and 9.7% in 2010; 83.3% of infections were subclinical (50% in 2009 and 85.9% in 2010). The 2-yr cumulative incidence was lowest (5%) in adults born ≤1957. The A(H1N1)pdm09 secondary attack rate among household contacts was 47.2% (17/36); 47.1% of these infections were subclinical. The highest A(H1N1)pdm09 secondary attack rate among household contacts (70.6%, 12/17) occurred among children born between 1990 and 2003. Subclinical A(H1N1)pdm09 infections in Thai adults occurred frequently and accounted for a greater proportion of all A(H1N1)pdm09 infections than previously estimated. The role of subclinical infections in A(H1N1)pdm09 transmission has important implications in formulating strategies to predict and prevent the spread of A(H1N1)pdm09 and other influenza virus strains.
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影响因子：
6.4
作者：
France, Anne Marie;Jackson, Michael;Hadler, James
通讯作者：
Hadler, James
DOI：
10.1056/nejmoa0905498
发表时间：
2009-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Cauchemez S;Donnelly CA;Reed C;Ghani AC;Fraser C;Kent CK;Finelli L;Ferguson NM
通讯作者：
Ferguson NM
影响因子：
3.7
作者：
Cox CM;Goodin K;Fisher E;Dawood FS;Hamilton JJ;Leparc GF;Gray M;Nelson L;Borse RH;Singleton JA;Reed C;Balish AL;Katz JM;Hopkins RS;Fry AM
通讯作者：
Fry AM
影响因子：
8.8
作者：
Kayali, Ghazi;Setterquist, Sharon F.;Gray, Gregory C.
通讯作者：
Gray, Gregory C.
影响因子：
4.4
作者：
Capuano, Ana W.;Dawson, Jeffrey D.;Gray, Gregory C.
通讯作者：
Gray, Gregory C.