Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting.
Old Brains Come Uncoupled in Sleep: Slow Wave-Spindle Synchrony, Brain Atrophy, and Forgetting.
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DOI：
10.1016/j.neuron.2017.11.020
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发表时间：
2018-01-03
期刊：
影响因子：
16.2
通讯作者：
Walker MP
中科院分区：
文献类型：
--
作者：
Helfrich RF;Mander BA;Jagust WJ;Knight RT;Walker MP
在非快速眼动（NREM）睡眠中，慢波振荡和睡眠纺锤波之间的耦合相互作用支持记忆巩固。然而，在人类身上几乎没有证据支持这一理论。此外，这种动态耦合是否会因晚年大脑衰老而受损，从而导致认知和记忆衰退，目前尚不清楚。结合脑电图（EEG），结构MRI和睡眠依赖记忆评估，我们在认知正常的年轻人和老年人中解决了这些问题。定向交叉频率耦合分析表明，慢波控制着睡眠纺锤波的精确时间协调，其质量预测了夜间记忆的保持。此外，老年人内侧额叶皮层的选择性萎缩预示着这种慢波-纺锤体耦合的时间分散，损害了夜间记忆巩固，导致遗忘。非快速眼动睡眠振荡时空协调的前额叶依赖缺陷为年龄相关的记忆衰退提供了一条潜在途径。Helfrich等人证明，睡眠脑电波之间的精确耦合，称为慢波和纺锤波，支持记忆保持。然而，老年人睡眠时的这种脑电波耦合由于内侧额叶组织的损失而受损，导致第二天的遗忘。
The coupled interaction between slow wave oscillations and sleep spindles during non-rapid-eye-movement (NREM) sleep has been proposed to support memory consolidation. However, little evidence in humans supports this theory. Moreover, whether such dynamic coupling is impaired as a consequence of brain aging in later life, contributing to cognitive and memory decline, is unknown. Combining, electroencephalography (EEG), structural MRI and sleep-dependent memory assessment, we addressed these questions in cognitively normal young and older adults. Directional cross-frequency coupling analyses demonstrated that the slow wave governs a precise temporal coordination of sleep spindles, the quality of which predicts overnight memory retention. Moreover, selective atrophy within the medial frontal cortex in older adults predicted a temporal dispersion of this slow wave-spindle coupling, impairing overnight memory consolidation leading to forgetting. Prefrontal dependent deficits in the spatiotemporal coordination of NREM sleep oscillations provide a potential pathway to age-related memory decline. Helfrich et al. demonstrate that the precise coupling between sleeping brainwaves, called slow waves and spindles, supports memory retention. However, this brainwave coupling during sleep is impaired in older adults due to loss of tissue in the medial frontal lobe, resulting next-day forgetting.
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