Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigm.
Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigm.
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DOI：
10.1002/da.20569
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发表时间：
2009
影响因子：
7.4
通讯作者：
Rauch, Scott L.
中科院分区：
文献类型：
--
作者：
Britton, Jennifer C.;Gold, Andrea L.;Deckersbach, Thilo;Rauch, Scott L.
情绪干扰任务可能有助于探测前扣带皮层（ACC）功能，以了解特定恐惧症患者的异常注意控制。在3T功能性MRI扫描仪中，患有特定动物亚型恐惧症的个体（SAP, n=12）和健康对照成人（HC, n=12）完成了与事件相关的情绪计数Stroop （ecStroop）任务。研究人员向受试者展示了与恐惧症相关的、消极的和中性的词语，并指示他们通过按下按钮来报告每次试验中显示的词语数量。与HC组相比，SAP组表现出更大的吻侧ACC激活（即对恐惧相关词语的反应大于中性词语）。在同样的对比中，与SAP组相比，hc组表现出更大的右侧杏仁核和后岛激活以及更大的丘脑失活。两组均表现出前扣带、背内侧前额叶皮层（dmPFC）、下额回/脑岛和杏仁核激活以及丘脑失活。心理生理相互作用（PPI）分析强调了在SAP组中，这些区域在面对与恐惧症相关的词语时的激活网络。综上所述，这些发现暗示了与SAP患者注意力异常有关的功能障碍回路。
Emotional interference tasks may be useful in probing anterior cingulate cortex (ACC) function to understand abnormal attentional control in individuals with specific phobia. In a 3T functional MRI scanner, individuals with specific phobias of the animal subtype (SAP, n=12) and healthy comparison adults (HC, n=12) completed an event-related emotional counting Stroop (ecStroop) task. Individuals were presented phobia-related, negative, and neutral words and were instructed to report via button-press the number of words displayed on each trial. Compared to the HC group, the SAP group exhibited greater rostral ACC activation (i.e., greater response to phobia-related words than neutral words). In this same contrast, HCs exhibited greater right amygdala and posterior insula activations as well as greater thalamic deactivations than the SAP group. Both groups exhibited anterior cingulate, dorsomedial prefrontal cortex (dmPFC), inferior frontal gyrus/insula, and amygdala activations as well as thalamic deactivations. Psychophysiological interaction (PPI) analysis highlighted a network of activation in these regions in response to phobia-related words in the SAP group. Taken together, these findings implicate a circuit of dysfunction that is linked to attention abnormalities in individuals with SAP.
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