Association of alcohol use biomarkers and cognitive performance in veterans with problematic alcohol use and posttraumatic stress disorder: data from the mind your heart study.

Association of alcohol use biomarkers and cognitive performance in veterans with problematic alcohol use and posttraumatic stress disorder: data from the mind your heart study.
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DOI:
10.1080/10550887.2014.909701
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发表时间:
2014
影响因子:
2.3
通讯作者:
Cohen BE
Cohen BE
中科院分区:
医学4区
文献类型:
--
作者:
Kalapatapu RK;Neylan TC;Regan MC;Cohen BE

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我们对85名有酗酒问题和创伤后应激障碍(PTSD)的退伍军人进行了一项酒精使用生物标志物和认知表现的研究。所有的分析都调整了人口统计学,抑郁,焦虑和创伤后应激障碍症状。天冬氨酸氨基转移酶(AST)水平升高与连线测试A部分和霍普金斯语言学习测试的表现较差相关。另外两种生物标志物与任何神经认知指标无关。间接酒精使用生物标志物(例如,AST)可能在识别那些有问题的酒精使用和创伤后应激障碍的退伍军人中发挥特定作用,这些退伍军人表现出心理速度和即时言语记忆表现的变化。
We conducted a study of alcohol use biomarkers and cognitive performance among 85 veterans with problematic alcohol use and posttraumatic stress disorder (PTSD). All analyses were adjusted for demographics, depression, anxiety, and PTSD symptoms. Elevated levels of aspartate aminotransferase (AST) were associated with worse performance on the Trail Making Test Part A and Hopkins Verbal Learning Test. Two other biomarkers were not associated with any neurocognitive measures. Indirect alcohol use biomarkers (e.g., AST) may have a specific role in identifying those veterans with problematic alcohol use and PTSD who show a change in psychomotor speed and immediate verbal memory performance.
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