Olfactory function and schizophrenia: an update

Olfactory function and schizophrenia: an update
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嗅觉功能和精神分裂症:更新

DOI:
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发表时间:
2010
影响因子:
6.9
通讯作者:
C. Rupp
C. Rupp
中科院分区:
医学2区
文献类型:
--
作者:
C. Rupp

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综述目的嗅觉是精神分裂症研究中一个日益受到关注的领域。本文就近年来有关精神分裂症患者嗅觉功能的研究作一综述。最新发现目前的文献为精神分裂症患者的嗅觉缺陷、异常和嗅觉享乐功能障碍提供了更多的见解。最近的发现加强了与阴性症状和缺陷综合征精神分裂症的特殊联系。研究表明,精神分裂症患者的异常延伸到更多的外周嗅觉结构和功能,包括嗅觉感受器神经元功能障碍。嗅觉识别能力被发现与年轻高危患者的前驱症状有关。进一步支持基因对精神分裂症嗅觉功能障碍的贡献的研究报告了未受影响的亲属的生理性嗅觉功能障碍(嗅觉事件相关电位),以及在精神分裂症患者和家庭成员中存在的气味特异性异常症。总结:需要进一步的研究来提高我们对精神分裂症患者嗅觉功能障碍的理解。最近令人鼓舞的发现强调,嗅觉系统是一个研究领域,有望促进我们对精神分裂症的病理生理学的理解,并可能成为神经发育脆弱性的有用的内表型标记。
Purpose of review Olfaction is a field of growing interest in schizophrenia research. This article reviews recent studies on olfactory functions in schizophrenia. Recent findings The current literature provides additional insights into olfactory deficits, abnormalities, and olfactory hedonic dysfunction in schizophrenia. Recent findings reinforce particular associations with negative symptoms and deficit syndrome schizophrenia. Studies indicate that abnormalities in patients with schizophrenia extend to more peripheral olfactory structures and functions, including olfactory receptor neuron dysfunction. Olfactory identification ability was found to relate to prodromal disorganization symptoms in young high-risk patients. Further support for the notion of a genetic contribution to olfactory dysfunction in schizophrenia derives from studies reporting physiological olfactory dysfunction (olfactory event-related potentials) in unaffected relatives, and an odor-specific hyposmia, present in both patients with schizophrenia and family members. Summary Further research is needed to improve our understanding of olfactory dysfunction in schizophrenia. Recent encouraging findings underscore that the olfactory system is a field of research that holds promise for advancing our understanding of the pathophysiology of schizophrenia and possibly as a useful endophenotypic marker of neurodevelopmental vulnerability.
精神分裂症面部情绪识别与气味识别之间的关联。
DOI: 10.1176/jnp.2007.19.2.128
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