Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD.
Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD.
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DOI：
10.1183/09031936.00066414
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Hopkinson NS
中科院分区：
文献类型：
--
作者：
Maddocks M;Shrikrishna D;Vitoriano S;Natanek SA;Tanner RJ;Hart N;Kemp PR;Moxham J;Polkey MI;Hopkinson NS
四头肌表型在慢性阻塞性肺疾病（COPD）患者之间差异很大，并且在没有肌肉活检的情况下无法确定。我们假设骨骼肌肥胖的措施可以提供非侵入性的生物标志物的肌肉质量在这个群体。在101名患者和10名年龄匹配的健康对照中，使用计算机断层扫描图像和标准组织衰减范围计算大腿中部横截面积、肌内脂肪百分比和骨骼肌衰减：脂肪-190- -30 HU;骨骼肌-29-150 HU。患者组的平均±sd肌内脂肪百分比较高（6.7±3.5% vs 4.3± 1.2%，p = 0.03）。肌内脂肪百分比和骨骼肌衰减与体力活动水平、运动能力和I型纤维比例相关，与年龄、大腿中段横截面积和股四头肌力量无关。结合一氧化碳的肺转移因子，这些变量可以识别>80%的纤维类型转移患者，特异性>65%（曲线下面积0.83，95%CI 0.72-0.95）。通过计算机断层扫描评估的骨骼肌肥胖反映了COPD相关肌肉功能障碍的多个方面，可能有助于识别针对特定肌肉表型的干预试验的患者。基于CT的骨骼肌肥胖标志物反映了COPD的肌肉质量，有助于识别纤维移位患者http://ow.ly/xolWA
Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We hypothesised that measures of skeletal muscle adiposity could provide noninvasive biomarkers of muscle quality in this population. In 101 patients and 10 age-matched healthy controls, mid-thigh cross-sectional area, percentage intramuscular fat and skeletal muscle attenuation were calculated using computed tomography images and standard tissue attenuation ranges: fat -190– -30 HU; skeletal muscle -29–150 HU. Mean±sd percentage intramuscular fat was higher in the patient group (6.7±3.5% versus 4.3±1.2%, p = 0.03). Both percentage intramuscular fat and skeletal muscle attenuation were associated with physical activity level, exercise capacity and type I fibre proportion, independent of age, mid-thigh cross-sectional area and quadriceps strength. Combined with transfer factor of the lung for carbon monoxide, these variables could identify >80% of patients with fibre type shift with >65% specificity (area under the curve 0.83, 95% CI 0.72–0.95). Skeletal muscle adiposity assessed by computed tomography reflects multiple aspects of COPD related muscle dysfunction and may help to identify patients for trials of interventions targeted at specific muscle phenotypes. CT-based skeletal muscle adiposity markers reflect muscle quality in COPD and help identify patients with fibre shift http://ow.ly/xolWA
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影响因子：
3.3
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
通讯作者：
Newman, AB
DOI：
10.1359/jbmr.090807
发表时间：
2010-03
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Lang T;Cauley JA;Tylavsky F;Bauer D;Cummings S;Harris TB;Health ABC Study
通讯作者：
Health ABC Study
影响因子：
64.5
作者：
Narkar VA;Downes M;Yu RT;Embler E;Wang YX;Banayo E;Mihaylova MM;Nelson MC;Zou Y;Juguilon H;Kang H;Shaw RJ;Evans RM
通讯作者：
Evans RM
DOI：
10.1046/j.1365-201x.2003.01162.x
发表时间：
2003-08-01
期刊：
ACTA PHYSIOLOGICA SCANDINAVICA
影响因子：
--
作者：
Hegarty, BD;Furler, SM;Kraegen, EW
通讯作者：
Kraegen, EW
影响因子：
15.9
作者：
LILLIOJA, S;YOUNG, AA;BOGARDUS, C
通讯作者：
BOGARDUS, C