Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China
Sporadic fundic gland polyps are not associated with proton pump inhibitors therapy but negatively correlate with Helicobacter pylori infection in China
复制标题
在中国，散发性胃底腺息肉与质子泵抑制剂治疗无关，但与幽门螺杆菌感染呈负相关
DOI：
10.3760/cma.j.issn.0366-6999.20133068
复制
发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Wang B
中科院分区：
文献类型：
--
作者：
Kong X;Wang S;Jiang K;Wang B
背景散发性胃底腺息肉(FGP)是常见的胃息肉。一些研究报道，由于质子泵抑制剂(PPI)的使用和西方国家幽门螺杆菌(H.Pylori)感染率的下降，FGP显著增加。然而，数据仍存在争议。本研究旨在探讨这两个因素与中国的FGPs之间的关系。方法对连续检出FGPs的病例进行回顾性分析。记录了患者的年龄、性别、症状、幽门螺杆菌感染、PPI使用史和息肉。在同一时期，每个患者都与随机选择的两个年龄和性别匹配、症状相似的对照组进行比较。结果2011年3月至2012年3月，在23047例行常规食管胃十二指肠镜检查的患者和656例未行FGPS的患者中，共有328例患者被诊断为FGPS。平均年龄(55.12±12.61)岁，女性占75.91%。幽门螺杆菌感染率组22.30%，对照组42.26%，差异有统计学意义(P<；0.001，OR 0.392，95%CI 0.283~0.544)。总体而言，54例FGPS患者(16.46%)和136例非FGPS患者(20.73%)接受了PPIs治疗(P=0.110)。根据PPI使用年限的不同，各亚组间PPI使用情况差异无统计学意义。此外，无论年龄、性别、幽门螺杆菌感染和息肉数量，PPI的使用也是相似的。结论在中国患者中，散发性FGP可能不是由PPI治疗诱发的，而是与H.
Background Sporadic fundic gland polyps (FGPs) are common gastric polyps. Some studies reported that FGPs dramatically increased due to proton pump inhibitors (PPIs) use and a decreased prevalence of Helicobacter pylori (H. pylori) infection in Western countries. However, data are still controversial. This study aimed to identify the relationships between these two factors and FGPs in China. Methods Consecutive patients with FGPs detected were retrospectively analyzed. Data including patients’ age, sex, symptoms, H. pylori infection, history of PPIs use, and the polyps were documented. Each patient was compared with two randomly selected age‐ and sex‐matched controls with similar symptoms in the same period. Results During the period from March 2011 to March 2012, a total of 328 patients were diagnosed as FGPs in 23 047 patients who underwent routine esophagogastroduodenoscopy and 656 patients without FGPs as controls. The mean age was (55.12±12.61) years, and 75.91% were women. The prevalence of H. pylori in patients with FGPs was significantly lower than in those without FGPs (22.30% (64/287) vs. 42.26% (224/530), P <0.001, OR 0.392, 95% Cl 0.283–0.544). Overall, a total of 54 patients with FGPs (54/328, 16.46%) and 136 patients without FGPs (136/656, 20.73%) received PPIs therapy (P=0.110). According to the different duration of PPIs use, no significant differences of PPIs use were found between the cases and controls among all subgroups. Moreover, the PPIs use was also similar, regardless of age, sex, H. pylori infection, and the number of polyps. Conclusion Sporadic FGPs may not be induced by PPIs therapy but negatively correlate with H. pylori infection in China, which is not the same with the data in Western countries.
登录
查看更多内容
胃息肉分布趋势：24 121例中国北方患者内镜数据库分析
DOI：
10.1111/j.1440-1746.2012.07116.x
发表时间：
2012-07-01
影响因子：
4.1
作者：
Cao, Hailong;Wang, Bangmao;Qu, Rui
通讯作者：
Qu, Rui
DOI：
--
发表时间：
1997-10
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
H. El-Zimaity;F. W. Jackson;D. Y. Graham
通讯作者：
H. El-Zimaity;F. W. Jackson;D. Y. Graham
影响因子：
3.1
作者：
Zelter, Adriana;Luis Fernandez, Jose;Alberto Viola, Luis
通讯作者：
Alberto Viola, Luis
影响因子：
3.2
作者：
Pregun, Istvan;Herszenyi, Laszlo;Tulassay, Zsolt
通讯作者：
Tulassay, Zsolt
影响因子：
7.5
作者：
Torbenson, M;Lee, JH;Wu, TT
通讯作者：
Wu, TT