Chemical standards in ion mobility spectrometry.
Chemical standards in ion mobility spectrometry.
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DOI：
10.1039/b915202d
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发表时间：
2010-06
期刊：
影响因子：
--
通讯作者：
Hill HH Jr
中科院分区：
文献类型：
--
作者：
Fernández-Maestre R;Harden CS;Ewing RG;Crawford CL;Hill HH Jr
在离子迁移谱 (IMS) 中，折合迁移率值 (K0) 用作气相离子的定性测量，并在文献中以绝对值形式报告。不幸的是，这些值并不总是与现场收集的值相符。造成这种差异的原因之一是缓冲气体可能被水分或其他挥发性化合物污染。在本研究中，首次使用 IMS 直接与质谱联用研究了缓冲气体中的水分和有机污染物对 IMS 标准品和分析物迁移率的影响。使用2,4-二甲基吡啶、2,6-二叔丁基吡啶(DTBP)以及四丁基氯化铵、四丙基氯化铵、四乙基氯化铵和四甲基氯化铵作为化学标准品。一般来说，IMS 标准产物离子的迁移率不会受到少量污染的影响，但许多分析物的迁移率会受到影响。当缓冲气体中存在污染物时，分析物离子的迁移率通常会因与污染物形成离子分子簇而降低。为了确保准确测量降低的迁移率值，需要两个 IMS 标准：仪器和迁移率标准。仪器标准不受缓冲气体中污染物的影响，并提供仪器参数的精确测量，例如电压、漂移长度、压力和温度。迁移率标准品的行为类似于分析物离子，因为化合物的迁移率受到缓冲气体中低水平污染的影响。谨慎使用这两个标准可以改进对准确的降低迁移率值的测量。
In ion mobility spectrometry (IMS), reduced mobility values (K0) are used as a qualitative measure of gas phase ions, and are reported in the literature as absolute values. Unfortunately, these values do not always match those collected in the field. One reason for this discrepancy is that the buffer gas may be contaminated with moisture or other volatile compounds. In this study, the effect of moisture and organic contaminants in the buffer gas on the mobility of IMS standards and analytes was investigated for the first time using IMS directly coupled to mass spectrometry. 2,4-dimethylpyridine, 2,6-di-tert-butyl pyridine (DTBP), and tetrabutylammonium, tetrapropylammonium, tetraethylammonium, and tetramethylammonium chlorides were used as chemical standards. In general, the mobility of IMS standard product ions was not affected by small amounts of contamination while the mobilities of many analytes were affected. In the presence of contaminants in the buffer gas, the mobility of analyte ions is often decreased by forming ion-molecule clusters with the contaminant. To ensure the measurement of accurate reduced mobility values, two IMS standards are required: an instrument and a mobility standard. An instrument standard is not affected by contaminants in the buffer gas, and provides an accurate measurement of the instrumental parameters, such as voltage, drift length, pressure, and temperature. The mobility standard behaves like an analyte ion in that the compound’s mobility is affected by low levels of contamination in the buffer gas. Prudent use of both of these standards can lead to improved measurement of accurate reduced mobility values.
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影响因子：
7.4
作者：
Dwivedi, Prabha;Wu, Ching;Hill, Herbert H., Jr.
通讯作者：
Hill, Herbert H., Jr.
影响因子：
7.4
作者：
GRIFFIN, GW;DZIDIC, I;HORNING, EC
通讯作者：
HORNING, EC
影响因子：
7.4
作者：
KARPAS, Z
通讯作者：
KARPAS, Z
影响因子：
1.3
作者：
COHEN, MJ;KARASEK, FW
通讯作者：
KARASEK, FW
影响因子：
6.2
作者：
Asbury, GR;Wu, C;Hill, HH
通讯作者：
Hill, HH