Advances in noninvasive myelin imaging.

Advances in noninvasive myelin imaging.
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DOI:
10.1002/dneu.22552
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发表时间:
2018-03
影响因子:
3
通讯作者:
Sampaio-Baptista C
Sampaio-Baptista C
中科院分区:
医学3区
文献类型:
--
作者:
Heath F;Hurley SA;Johansen-Berg H;Sampaio-Baptista C

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髓鞘对神经系统的正常发育和健康功能很重要。MRI采集和组织建模的最新发展旨在为髓鞘提供更好的表征和更特异的标记物。这允许在健康大脑中纵向和非侵入性地特异性监测髓鞘形成以及评估治疗和干预功效。在这里,我们提供了一个非技术性的审查磁共振成像技术,专门监测髓鞘,如磁化传递(MT)和髓鞘水成像(MWI)。我们进一步总结了最近的研究,采用这些方法来衡量髓鞘的发展和衰老,学习和经验,神经病理学和精神疾病。版权所有© 2017作者.出版社:Wiley Periodicals,Inc.开发神经生物学78:136-151,2018
Myelin is important for the normal development and healthy function of the nervous system. Recent developments in MRI acquisition and tissue modeling aim to provide a better characterization and more specific markers for myelin. This allows for specific monitoring of myelination longitudinally and noninvasively in the healthy brain as well as assessment of treatment and intervention efficacy. Here, we offer a nontechnical review of MRI techniques developed to specifically monitor myelin such as magnetization transfer (MT) and myelin water imaging (MWI). We further summarize recent studies that employ these methods to measure myelin in relation to development and aging, learning and experience, and neuropathology and psychiatric disorders. © 2017 The Authors. Developmental Neurobiology Published by Wiley Periodicals, Inc. Develop Neurobiol 78: 136–151, 2018
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