Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.
Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.
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DOI：
10.1016/j.chom.2018.03.002
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发表时间：
2018-04-11
影响因子：
30.3
通讯作者：
van den Brink MRM
中科院分区：
文献类型：
--
作者：
Staffas A;Burgos da Silva M;Slingerland AE;Lazrak A;Bare CJ;Holman CD;Docampo MD;Shono Y;Durham B;Pickard AJ;Cross JR;Stein-Thoeringer C;Velardi E;Tsai JJ;Jahn L;Jay H;Lieberman S;Smith OM;Pamer EG;Peled JU;Cohen DE;Jenq RR;van den Brink MRM
骨髓移植（BMT）为高危恶性血液病患者提供了治疗潜力，但移植后阶段的特点是严重的免疫缺陷。最近的研究表明，肠道微生物群不仅调节粘膜免疫，而且还有助于全身免疫和造血。在同基因BMT小鼠模型中使用抗生素介导的微生物群耗竭，在此我们描述了肠道植物群在BMT后造血恢复中的作用。肠道微生物群的消耗导致淋巴细胞和中性粒细胞计数的恢复受损，而造血干细胞和祖细胞隔室以及红细胞系的恢复在很大程度上不受影响。肠道微生物群的消耗也减少了膳食能量的摄取和内脏脂肪的储存。通过饮用水中的蔗糖补充热量改善了肠道植物群耗尽的小鼠的骨髓移植后造血恢复。总之，我们表明肠道微生物群通过改善膳食能量摄取有助于小鼠骨髓移植后造血重建。肠道菌群可影响全身造血功能。Staffas等人表明，肠道植物群通过改善饮食能量摄取有助于骨髓移植（BMT）后的造血恢复。研究结果表明，可能的临床干预策略，以改善骨髓移植的结果。
Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to systemic immunity and hematopoiesis. Using antibiotic-mediated microbiota depletion in a syngeneic BMT mouse model, here we describe a role for the intestinal flora in hematopoietic recovery after BMT. Depletion of the intestinal microbiota resulted in impaired recovery of lymphocyte and neutrophil counts, while recovery of the hematopoietic stem- and progenitor-compartments and the erythroid lineage were largely unaffected. Depletion of the intestinal microbiota also reduced dietary energy uptake and visceral fat stores. Caloric supplementation through sucrose in the drinking water improved post-BMT hematopoietic recovery in mice with a depleted intestinal flora. Taken together, we show that the intestinal microbiota contribute to post-BMT hematopoietic reconstitution in mice through improved dietary energy uptake. Intestinal bacteria can exert effects on systemic hematopoiesis. Staffas et al show that the intestinal flora contributes to hematopoietic recovery after bone-marrow transplantation (BMT) through improved dietary-energy uptake. The findings suggest possible clinical intervention strategies for improved BMT outcomes.
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影响因子：
4.5
作者：
Elegido, Ana;Graell, Montserrat;Nova, Esther
通讯作者：
Nova, Esther
影响因子：
3.7
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Clifford RJ;Milillo M;Prestwood J;Quintero R;Zurawski DV;Kwak YI;Waterman PE;Lesho EP;Mc Gann P
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影响因子：
30.3
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通讯作者：
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影响因子：
3.1
作者：
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通讯作者：
BERG, RD
影响因子：
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作者：
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通讯作者：
Lee, KB