Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy.
Evaluation of amino acid profile in serum of patients with Covid-19 for providing a new treatment strategy.
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DOI：
10.5937/jomb0-37514
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发表时间：
2022-10-15
影响因子：
2.5
通讯作者：
Resat CM
中科院分区：
文献类型：
--
作者：
Ozturk A;Bayraktar N;Bayraktar M;Ibrahim B;Bozok T;Resat CM
氨基酸在代谢中发挥重要作用，可能影响COVID-19相关结果。在我们的研究中，对住院COVID 19患者的血清氨基酸水平进行了评估，以确定新的治疗策略。检查了68名受试者的氨基酸谱，包括30名（14名男性和16名女性）对照和38名（16名男性和22名女性）COVID-19患者。通过LC-MS/MS筛选参与者的氨基酸谱。与对照组相比，患者组血清中27种氨基酸水平升高。对照组的α-氨基庚二酸、肌氨酸和羟脯氨酸氨基酸显著高于患者组（p<0.0001）。13种氨基酸在对照组和病例组之间差异无显著性（p≥0.05）。在对照组和患者组的平均氨基酸值中观察到显著的正相关（r=0.937; p<0.0001）。该等结果为COVID-19患者的血清氨基酸水平提供了清晰的图像。在住院的COVID-19患者中测量的血清氨基酸可以解释患者在疾病期间的代谢状态。
Amino acids have an important role in metabolism and may affect COVID-19-related outcomes. In our study, the amino acid serum level of hospitalized COVID19 patients was evaluated to determine a new treatment strategy. The amino acid profile covering 43 amino acids in 68 subjects, comprising 30 (14 men and 16 women) controls and 38 (16 men and 22 women) COVID-19 patients, were examined. The amino acid profiles of the participants were screened by LC-MS/MS. Compared with the control group, serum levels of 27 amino acids increased in the patient group. Alpha-aminopimelic acid, sarcosine, and hydroxyproline amino acids were considerably higher in the control group than in the patient group (p<0.0001). There was no notable difference among control group and the case group for 13 amino acids (p≥0.05). A significant positive correlation was seen among the control and the patient groups in the mean amino acid values (r=0.937; p<0.0001). These results postulated a clear picture on the serum levels of amino acid in the COVID-19 patients. Serum amino acids measured in hospitalized COVID-19 patients can explain the patient's metabolic status during the disease.
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影响因子：
7.3
作者：
Ren W;Rajendran R;Zhao Y;Tan B;Wu G;Bazer FW;Zhu G;Peng Y;Huang X;Deng J;Yin Y
通讯作者：
Yin Y
影响因子：
3.6
作者：
Kim IY;Park S;Jang J;Wolfe RR
通讯作者：
Wolfe RR
DOI：
10.1073/pnas.2101708118
发表时间：
2021-06-22
影响因子：
11.1
作者：
Rees CA;Rostad CA;Mantus G;Anderson EJ;Chahroudi A;Jaggi P;Wrammert J;Ochoa JB;Ochoa A;Basu RK;Heilman S;Harris F;Lapp SA;Hussaini L;Vos MB;Brown LA;Morris CR
通讯作者：
Morris CR
影响因子：
9
作者：
Danlos FX;Grajeda-Iglesias C;Durand S;Sauvat A;Roumier M;Cantin D;Colomba E;Rohmer J;Pommeret F;Baciarello G;Willekens C;Vasse M;Griscelli F;Fahrner JE;Goubet AG;Dubuisson A;Derosa L;Nirmalathasan N;Bredel D;Mouraud S;Pradon C;Stoclin A;Rozenberg F;Duchemin J;Jourdi G;Ellouze S;Levavasseur F;Albigès L;Soria JC;Barlesi F;Solary E;André F;Pène F;Ackerman F;Mouthon L;Zitvogel L;Marabelle A;Michot JM;Fontenay M;Kroemer G
通讯作者：
Kroemer G
影响因子：
4.1
作者：
Kim Y;Park S;Lee J;Jang J;Jung J;Koh JH;Choi CS;Wolfe RR;Kim IY
通讯作者：
Kim IY