Association of frailty with influenza and hospitalization due to influenza among independent older adults: a longitudinal study of Japan Gerontological Evaluation Study (JAGES).
Association of frailty with influenza and hospitalization due to influenza among independent older adults: a longitudinal study of Japan Gerontological Evaluation Study (JAGES).
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DOI：
10.1186/s12877-023-03979-y
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发表时间：
2023-04-26
期刊：
影响因子：
4.1
通讯作者：
Kondo, Katsunori
中科院分区：
文献类型：
--
作者：
Iwai-Saito, Kousuke;Sato, Koryu;Aida, Jun;Kondo, Katsunori
目前尚不清楚，在老年人中，虚弱是否是流感和住院的一个危险因素，尽管已经表明，在老年人中，虚弱与住院后恢复不良有关。我们研究了在独立老年人中虚弱与流感和住院治疗的关系以及性别的影响。我们使用了日本老年学评估研究（JAGES）的纵向数据，该研究于2016年和2019年在日本28个城市进行。目标人口包括77,103名年龄≥65岁的人，他们不需要公共长期护理保险的帮助。主要结局指标为流感和因流感住院。虚弱是用基洪检查表来评估的。我们使用泊松回归对协变量进行调整，估计流感的风险、住院的风险、按性别划分的风险以及虚弱和性别之间的相互作用。调整协变量后，老年人与非虚弱个体相比，虚弱与流感和住院均相关（流感，虚弱：风险比{RR}: 1.36, 95%可信区间{95% CI}: 1.20 - 1.53，虚弱前期：RR: 1.16, 95% CI: 1.09 - 1.23；住院，虚弱：RR: 3.18, 95% CI: 1.84 - 5.57，虚弱前期：RR: 2.13, 95% CI: 1.44 - 3.16）。男性与住院相关，但与流感无关（住院：RR: 1.70, 95% CI: 1.15 - 2.52；流感：RR: 1.01, 95% CI: 0.95 - 1.08）。虚弱和性别的相互作用在流感和住院治疗中都不显著。这些结果表明，虚弱是流感和住院治疗的风险，住院治疗的风险因性别而异，但性别差异不导致虚弱对独立老年人易感性和严重程度的影响异质性。在线版本包含补充材料，可在10.1186/s12877-023-03979-y获得。
It is unknown that whether frailty is a risk factor of influenza and the hospitalization among older adults, although it has been shown that frailty was associated with poor recovery from the hospitalization among those. We examined the association of frailty with influenza and the hospitalization and the effect by sex among independent older adults. We used the longitudinal data from the Japan Gerontological Evaluation Study (JAGES), performed in 2016 and 2019 and conducted in 28 municipalities in Japan. The target population comprised 77,103 persons aged ≥ 65 years who did not need assistance from the public long-term care insurance. Primary outcome measures were influenza and hospitalization due to influenza. Frailty was evaluated with the Kihon check list. We estimated the risk of influenza, the hospitalization, those risks by sex, and the interaction for frailty and sex using Poisson regression adjusting for covariates. Frailty was associated with both influenza and the hospitalization among the older adults compared with nonfrail individuals after adjusting for covariates (influenza, frail: risk ratio {RR}: 1.36, 95% confidence interval {95% CI}: 1.20 − 1.53, and prefrail: RR: 1.16, 95% CI: 1.09 − 1.23; the hospitalization, frail: RR: 3.18, 95% CI: 1.84 − 5.57, and prefrail: RR: 2.13, 95% CI: 1.44 − 3.16). Male was associated with the hospitalization, but not associated with influenza compared to female (the hospitalization: RR: 1.70, 95% CI: 1.15 − 2.52 and influenza: RR: 1.01, 95% CI: 0.95 − 1.08). The interaction for frailty and sex was significant neither in influenza nor in the hospitalization. These results suggest that frailty is a risk of influenza and the hospitalization, that risks of the hospitalization are different by sex, but that the sex difference does not cause the effect heterogeneity of frailty on the susceptibility and severity among independent older adults. The online version contains supplementary material available at 10.1186/s12877-023-03979-y.
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影响因子：
4.6
作者：
Tsuji T;Kanamori S;Watanabe R;Yokoyama M;Miyaguni Y;Saito M;Kondo K
通讯作者：
Kondo K
脆弱但不是肌肉减少症和营养不良增加了在老年人居住成年人中发展共同19的风险。
影响因子：
4
作者：
Lengelé L;Locquet M;Moutschen M;Beaudart C;Kaux JF;Gillain S;Reginster JY;Bruyère O
通讯作者：
Bruyère O
影响因子：
2.9
作者：
Luo J;Tang W;Sun Y;Jiang C
通讯作者：
Jiang C
影响因子：
4.6
作者：
Iwai-Saito K;Shobugawa Y;Aida J;Kondo K
通讯作者：
Kondo K
影响因子：
1.6
作者：
Goto, Ryohei;Watanabe, Hiroki;Yanagi, Hisako
通讯作者：
Yanagi, Hisako