Frailty but not sarcopenia nor malnutrition increases the risk of developing COVID-19 in older community-dwelling adults.
Frailty but not sarcopenia nor malnutrition increases the risk of developing COVID-19 in older community-dwelling adults.
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脆弱但不是肌肉减少症和营养不良增加了在老年人居住成年人中发展共同19的风险。
DOI：
10.1007/s40520-021-01991-z
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发表时间：
2022-01
影响因子：
4
通讯作者：
Bruyère O
中科院分区：
文献类型：
--
作者：
Lengelé L;Locquet M;Moutschen M;Beaudart C;Kaux JF;Gillain S;Reginster JY;Bruyère O
要求确定2019冠状病毒病（COVID-19）危险因素，以实施预防战略。探讨COVID-19发病率与营养不良、肌肉减少症和虚弱之间的关系，这些在以前的横断面研究中被确定为潜在的危险因素。在骨骼肌减少症和高龄身体损伤（SarcoPhAge）队列（即截至2019年的第五年）的最后一次可用随访中，分别根据迷你营养评估简表、欧洲老年人骨骼肌减少症工作组（EWGSOP2）和Fried标准对营养不良、肌肉减少症和虚弱进行了评估。2021年4月，通过电话采访收集了有关COVID-19的信息，以衡量其自我宣布的发病率。采用校正Cox回归和Kaplan-Meier曲线。本研究纳入241名参与者[中位年龄75.6（73.0-80.6）岁，63.1%为女性]。其中，27名参与者（11.2%）发展为非致命性Covid-19。营养不良和肌肉减少患者发生COVID-19的风险未见显著增加[调整HR 1.14(0.26-5.07)]和[调整HR 1.25(0.35-4.42)]。然而，体弱者的COVID-19发病率（44.4%）明显高于健壮者（8.5%）[调整后危险度7.01 (2.69-18.25)]，Kaplan-Meier曲线证实了这一点（p < 0.001）。在虚弱综合征的组成部分中，低体力活动水平是唯一与COVID-19风险增加显著相关的因素[调整后HR 5.18(1.37-19.54)]。尽管本研究的方法存在一些局限性（即样本量有限，COVID-19发病率自我报告，未使用客观测量系统评估），需要仔细考虑，但在存在虚弱综合征的情况下，观察到发生COVID-19的风险增加。需要进一步的调查来详细说明我们的发现。在线版本包含补充材料，可在10.1007/s40520-021-01991-z获得。
The identification of coronavirus disease 2019 (COVID-19) risk factors is requested to implement prevention strategies. To explore the associations between the COVID-19 incidence and malnutrition, sarcopenia, and frailty, identified as potential risk factors in previous cross-sectional studies. Malnutrition, sarcopenia, and frailty were assessed at the last available follow-up from the Sarcopenia and Physical Impairments with Advancing Age (SarcoPhAge) cohort (i.e., the fifth year that ended in 2019) according to the Mini-Nutritional Assessment short-form, the European Working Group on Sarcopenia in Older People (EWGSOP2), and the Fried criteria, respectively. Information regarding the COVID-19 was gathered by phone calls interviews in April 2021 to measure its self-declared incidence. Adjusted Cox regressions and Kaplan–Meier curves were performed. The present study included 241 participants [median age 75.6 (73.0–80.6) years, 63.1% women]. Among them, 27 participants (11.2%) developed the non-fatal Covid-19. No significant increased risks of COVID-19 were observed in patients with malnutrition [adjusted HR 1.14 (0.26–5.07)] and sarcopenia [adjusted HR 1.25 (0.35–4.42)]. Nevertheless, the incidence of COVID-19 was significantly higher in frail (44.4%) than in robust participants (8.5%) [Adjusted HR 7.01 (2.69–18.25)], which was confirmed by the Kaplan–Meier curves (p < 0.001). Among the frailty syndrome components, a low physical activity level was the only one significantly associated with an increased risk of COVID-19 [adjusted HR 5.18 (1.37–19.54)]. Despite some limitations in the methodology of this study (i.e., limited sample size, COVID-19 incidence self-reported and not assessed systematically using objective measurements) requiring careful consideration, an increased risk to develop COVID-19 was observed in the presence of the frailty syndrome. Further investigations are needed to elaborate on our findings. The online version contains supplementary material available at 10.1007/s40520-021-01991-z.
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影响因子：
4.8
作者：
Coelho T;Paúl C;Gobbens RJ;Fernandes L
通讯作者：
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DOI：
10.1002/jcsm.12687
发表时间：
2021-04
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DOI：
10.1016/s1473-3099(21)00460-6
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2022-01
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影响因子：
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作者：
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通讯作者：
Steves CJ
DOI：
10.1016/0021-9681(86)90195-5
发表时间：
1986-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
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作者：
FOLSOM, AR;JACOBS, DR;KNUDSEN, J
通讯作者：
KNUDSEN, J