The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication.
The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication.
复制标题
全国合并症调查复制中强迫症的强迫症的流行病学。
DOI：
10.1038/mp.2008.94
复制
发表时间：
2010-01
影响因子：
11
通讯作者：
Kessler, R. C.
中科院分区：
文献类型：
--
作者：
Ruscio, A. M.;Stein, D. J.;Chiu, W. T.;Kessler, R. C.
关键词：
尽管强迫症（OCD）的研究取得了重大进展，但关于该疾病的公共卫生意义、适当的诊断分类和临床异质性等重要问题仍然存在。这些问题是利用国家共病调查复制（NCS-R）的数据来探讨的，这是一项针对美国成年人的全国性代表性调查。对2073名受访者的子样本进行了终身DSM-IV强迫症评估。超过四分之一的受访者表示，他们在生活中的某个时候经历过强迫或强迫行为。虽然强迫症的条件概率与报告的强迫和强迫的数量密切相关，但只有一小部分受访者完全符合DSM-IV的终身（2.3%）或12个月（1.2%）强迫症的标准。强迫症与大量的共病有关，不仅与焦虑和情绪障碍有关，还与冲动控制和物质使用障碍有关。强迫症的严重程度由耶鲁-布朗强迫症量表（Y-BOCS）进行评估，与洞察力差、高合并症、高角色障碍和高寻求治疗的可能性有关。阈下强迫症症状的高患病率可能有助于解释过去调查中患病率估计的不一致，并表明强迫症的公共卫生负担可能比其低患病率所暗示的要大。早发病例在男性中占主导地位，与多种疾病的高合并症，以及疾病严重程度和关键结果之间的可靠关联，这些证据可能对DSM-V中强迫症的分类产生影响。
Despite significant advances in the study of obsessive-compulsive disorder (OCD), important questions remain about the disorder's public health significance, appropriate diagnostic classification, and clinical heterogeneity. These issues were explored using data from the National Comorbidity Survey Replication (NCS-R), a nationally representative survey of U.S. adults. A subsample of 2073 respondents was assessed for lifetime DSM-IV OCD. More than one-quarter of respondents reported experiencing obsessions or compulsions at some time in their lives. While conditional probability of OCD was strongly associated with the number of obsessions and compulsions reported, only small proportions of respondents met full DSM-IV criteria for lifetime (2.3%) or 12-month (1.2%) OCD. OCD is associated with substantial comorbidity, not only with anxiety and mood disorders but also with impulse-control and substance use disorders. Severity of OCD, assessed by an adapted version of the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), is associated with poor insight, high comorbidity, high role impairment, and high probability of seeking treatment. The high prevalence of subthreshold OCD symptoms may help explain past inconsistencies in prevalence estimates across surveys and suggests that the public health burden of OCD may be greater than its low prevalence implies. Evidence of a preponderance of early-onset cases in males, high comorbidity with a wide range of disorders, and reliable associations between disorder severity and key outcomes may have implications for how OCD is classified in DSM-V.
登录
查看更多内容
影响因子：
7.3
作者：
Eisen, JL;Rasmussen, SA;Piggott, T
通讯作者：
Piggott, T
影响因子：
--
作者：
KARNO, M;GOLDING, JM;BURNAM, MA
通讯作者：
BURNAM, MA
影响因子：
120.7
作者：
Demyttenaere, K;Bruffaerts, R;Chatterji, S
通讯作者：
Chatterji, S
影响因子：
10.5
作者：
HOEHNSARIC, R;BARKSDALE, VC
通讯作者：
BARKSDALE, VC
影响因子：
10.6
作者：
Bienvenu, OJ;Samuels, JF;Nestadt, G
通讯作者：
Nestadt, G