Development and validation of a Monte Carlo simulation tool for multi-pinhole SPECT.
Development and validation of a Monte Carlo simulation tool for multi-pinhole SPECT.
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DOI：
10.1007/s11307-009-0263-7
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发表时间：
2010-06
影响因子：
3.1
通讯作者：
Tsui, Benjamin M. W.
中科院分区：
文献类型：
--
作者：
Mok, Greta S. P.;Du, Yong;Wang, Yuchuan;Frey, Eric C.;Tsui, Benjamin M. W.
在这项工作中，我们开发并验证了蒙特卡罗模拟（MCS）工具，用于研究和评估多针孔（MPH） SPECT成像。该工具是基于SimSET和MCNP代码的组合。在此工具中模拟了光子在目标中的衰减和散射，以及通过准直检测器的穿透和散射。它允许精确和有效的模拟MPH SPECT聚焦针孔孔径和用户指定的光子能量，孔径材料和成像几何。通过比较点响应函数（PRF）、检测效率（DE）以及从点光源和幻像实验中获得的图像轮廓，验证了MCS方法的有效性。在小型动物成像仪上安装了单针孔准直器和聚焦四针孔准直器和聚焦五针孔准直器进行了实验验证。我们还比较了MPH SPECT的各种模拟工具的计算速度，包括SimSET-MCNP， MCNP， SimSET-GATE和GATE，用于模拟热球幻影的投影。我们发现MCS和实验结果在PRF， DE和图像配置文件之间有很好的一致性，表明了仿真方法的有效性。对于120视图模拟，SimSET-MCNP、MCNP、SimSET-GATE和GATE的相对计算速度分别为1:2 .73:3.54:7.34。我们还演示了该MCS工具在小动物成像中的应用，通过生成一组3D数字小鼠全身幻影的低噪声MPH投影数据。该方法可用于研究MPH准直器的设计、数据采集协议、图像重建和补偿技术。在定量重建方法中，它也有很大的潜力用于模拟具有穿透和散射效应的MPH准直-探测器响应。
In this work, we developed and validated a Monte Carlo simulation (MCS) tool for investigation and evaluation of multi-pinhole (MPH) SPECT imaging. This tool was based on a combination of the SimSET and MCNP codes. Photon attenuation and scatter in the object, as well as penetration and scatter through the collimator detector, are modeled in this tool. It allows accurate and efficient simulation of MPH SPECT with focused pinhole apertures and user-specified photon energy, aperture material, and imaging geometry. The MCS method was validated by comparing the point response function (PRF), detection efficiency (DE), and image profiles obtained from point sources and phantom experiments. A prototype single-pinhole collimator and focused four- and five-pinhole collimators fitted on a small animal imager were used for the experimental validations. We have also compared computational speed among various simulation tools for MPH SPECT, including SimSET-MCNP, MCNP, SimSET-GATE, and GATE for simulating projections of a hot sphere phantom. We found good agreement between the MCS and experimental results for PRF, DE, and image profiles, indicating the validity of the simulation method. The relative computational speeds for SimSET-MCNP, MCNP, SimSET-GATE, and GATE are 1: 2.73: 3.54: 7.34, respectively, for 120-view simulations. We also demonstrated the application of this MCS tool in small animal imaging by generating a set of low-noise MPH projection data of a 3D digital mouse whole body phantom. The new method is useful for studying MPH collimator designs, data acquisition protocols, image reconstructions, and compensation techniques. It also has great potential to be applied for modeling the collimator-detector response with penetration and scatter effects for MPH in the quantitative reconstruction method.
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