Sex disparities matter in cancer development and therapy.
Sex disparities matter in cancer development and therapy.
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DOI：
10.1038/s41568-021-00348-y
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Haupt Y
中科院分区：
文献类型：
--
作者：
Haupt S;Caramia F;Klein SL;Rubin JB;Haupt Y
通过精准医学治愈癌症是新一波分子和基因组疗法的首要目标。目前，根据性染色体，非生殖性癌症患者是男性还是女性，在患者护理标准中没有得到充分考虑。这是一个后果问题，因为越来越多的证据表明，这些癌症类型通常发生得更早，与女性相比，男性的总体发病率和死亡率更高。性别，相对于性，指的是一种选择的性身份。危险的生活方式选择（特别是吸烟）在性别之间的流行程度不同，与不成比例的癌症风险相一致。这些增加了潜在的遗传易感性和性类固醇激素的影响。这些因素共同影响新陈代谢、免疫和炎症，最终影响遗传密码的保真度。为了准确地了解人类对癌症的防御是如何侵蚀的，确定性别的影响至关重要。我们的观点强调了基础和转化研究的证据，表明在癌症患者的治疗中包括遗传性别因素将改善结果。现在是时候接受基于女性和男性优化治疗策略的癌症医学改革的挑战了。
Curing cancer through precision medicine is the paramount aim of the new wave of molecular and genomic therapies. Currently, whether patients with non-reproductive cancers are male or female according to their sex chromosomes is not adequately considered in patient standard of care. This is a matter of consequence because there is growing evidence that these cancer types generally initiate earlier and are associated with higher overall incidence and rates of death in males compared with females. Gender, in contrast to sex, refers to a chosen sexual identity. Hazardous lifestyle choices (notably tobacco smoking) differ in prevalence between genders, aligned with disproportionate cancer risk. These add to underlying genetic predisposition and influences of sex steroid hormones. Together, these factors affect metabolism, immunity and inflammation, and ultimately the fidelity of the genetic code. To accurately understand how human defences against cancer erode, it is crucial to establish the influence of sex. Our Perspective highlights evidence from basic and translational research indicating that including genetic sex considerations in treatments for patients with cancer will improve outcomes. It is now time to adopt the challenge of overhauling cancer medicine based on optimized treatment strategies for females and males.
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DOI：
10.1158/1078-0432.ccr-16-3122
发表时间：
2017-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Brown JM;Recht L;Strober S
通讯作者：
Strober S
影响因子：
12.4
作者：
Carè A;Bellenghi M;Matarrese P;Gabriele L;Salvioli S;Malorni W
通讯作者：
Malorni W
影响因子：
4.6
作者：
Baars A;Oosting A;Lohuis M;Koehorst M;El Aidy S;Hugenholtz F;Smidt H;Mischke M;Boekschoten MV;Verkade HJ;Garssen J;van der Beek EM;Knol J;de Vos P;van Bergenhenegouwen J;Fransen F
通讯作者：
Fransen F
影响因子：
50.3
作者：
Andricovich J;Perkail S;Kai Y;Casasanta N;Peng W;Tzatsos A
通讯作者：
Tzatsos A
影响因子：
16.6
作者：
Barberio, Amanda M.;Alareeki, Asalah;Brenner, Darren R.
通讯作者：
Brenner, Darren R.