Over and above frequency: Gamma oscillations as units of neural circuit operations.

Over and above frequency: Gamma oscillations as units of neural circuit operations.
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DOI:
10.1016/j.neuron.2023.02.026
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发表时间:
2023-04-05
期刊:
影响因子:
16.2
通讯作者:
Dupret D
Dupret D
中科院分区:
医学1区
文献类型:
--
作者:
Fernandez-Ruiz A;Sirota A;Lopes-Dos-Santos V;Dupret D

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伽马振荡(≈30 - 150hz)是神经回路功能的广泛相关。这些网络活动模式已经在多个动物物种、大脑结构和行为中得到了描述,通常是基于它们的频谱峰值频率来识别的。然而,尽管进行了深入的研究,伽马振荡是否实现了特定脑功能的因果机制,还是代表了神经回路操作的一般动态模式,仍不清楚。在这方面,我们回顾了伽马振荡研究的最新进展,以更深入地了解它们的细胞机制、神经通路和功能作用。我们讨论了给定的伽马节律本身并不实现任何特定的认知功能,而是构成了一个活动基序,报告了在其产生的大脑回路中潜在的信息处理的细胞底物、通信通道和计算操作。因此,我们建议将注意力从基于频率的伽马振荡的定义转移到电路级定义。
Gamma oscillations (˜30–150 Hz) are widespread correlates of neural circuit functions. These network activity patterns have been described across multiple animal species, brain structures and behaviors, being usually identified based on their spectral peak frequency. Yet, despite intensive investigation, whether gamma oscillations implement causal mechanisms of specific brain functions or represent a general dynamic mode of neural circuit operation remains unclear. In this Perspective we review recent advances in the study of gamma oscillations towards a deeper understanding of their cellular mechanisms, neural pathways, and functional roles. We discuss that a given gamma rhythm does not per se implement any specific cognitive function but rather constitutes an activity motif reporting the cellular substrates, communication channels and computational operations underlying information processing in its generating brain circuit. Accordingly, we propose shifting the attention from a frequency-based to a circuit-level definition of gamma oscillations.
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