Long-term effects of curcumin in the non-human primate brain.
Long-term effects of curcumin in the non-human primate brain.
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DOI：
10.1016/j.brainresbull.2018.06.015
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发表时间：
2018-09
影响因子：
3.8
通讯作者：
Moore TL
中科院分区：
文献类型：
--
作者：
Koo BB;Calderazzo S;Bowley BGE;Kolli A;Moss MB;Rosene DL;Moore TL
姜黄素最近被证明是一种潜在的治疗方法，可以减缓或改善我们非人灵长类动物正常衰老模型中衰老过程中的认知下降。在这些相同的猴子中，我们首次使用纵向磁共振成像（MRI）研究了长期姜黄素治疗的神经影响。16只恒河猴接受姜黄素或载体对照14-18个月。我们应用结构和扩散MRI的组合来确定姜黄素是否导致大脑焦点区域的结构或功能变化。纵向成像显示姜黄素处理动物的海马和基底前脑结构中的微尺度扩散率（mD）测量值降低。广义各向异性分数（GFA）和灰质密度（GMd）测量值的变化表明皮质ROI中的灰质密度增加，边缘系统、小脑和脑干区域的白色物质完整性改善。这些发现表明，长期姜黄素治疗可以诱导神经元环境的显著变化。这些结果可能为最近的研究结果提供神经学基础，这些研究结果表明非人灵长类动物的空间工作记忆和运动功能得到了改善。
Curcumin has recently been shown to be a potential treatment for slowing or ameloriating cognitive decline during aging in our nonhuman primate model of normal aging. In these same monkeys, we studied for the first time the neurological impacts of long-term curcumin treatments using longitudinal magnetic resonance imaging (MRI). Sixteen rhesus monkeys received curcumin or a vehicle control for 14–18 months. We applied a combination of structural and diffusion MRI to determine whether the curcumin resulted in structural or functional changes in focal regions of the brain. The longitudinal imaging revealed decreased microscale diffusivity (mD) measurements mainly in the hippocampus and basal forebrain structures of curcumin treated animals. Changes in generalized fractional anisotropy (GFA) and grey matter density (GMd) measurements indicated an increased grey matter density in cortical ROIs with improved white matter integrity in limbic, cerebellar, and brain stem regions. These findings suggest that noticeable changes in the neuronal environment could be induced from long-term curcumin treatments. Results may provide a neurological basis on the recent findings demonstrating improved spatial working memory and motor function in nonhuman primates.
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影响因子：
3.7
作者：
Blumenfeld-Katzir T;Pasternak O;Dagan M;Assaf Y
通讯作者：
Assaf Y
DOI：
10.1016/j.biocel.2008.06.010
发表时间：
2009-01
影响因子：
4
作者：
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Harikumar, Kuzhuvelil B.
影响因子：
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作者：
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通讯作者：
O'Connor, JJ
影响因子：
5.5
作者：
CRAGG, BG;THOMAS, PK
通讯作者：
THOMAS, PK
影响因子：
11
作者：
Goshen, I.;Kreisel, T.;Yirmiya, R.
通讯作者：
Yirmiya, R.