Dissociation between dorsal and ventral posterior parietal cortical responses to incidental changes in natural scenes.
Dissociation between dorsal and ventral posterior parietal cortical responses to incidental changes in natural scenes.
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DOI：
10.1371/journal.pone.0067988
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Spiers HJ
中科院分区：
文献类型：
--
作者：
Howard LR;Kumaran D;Ólafsdóttir HF;Spiers HJ
The posterior parietal cortex (PPC) is thought to interact with the medial temporal lobe (MTL) to support spatial cognition and topographical memory.虽然内侧颞叶区域对地形刺激的反应已得到深入研究，但很少有研究关注 PPC 的作用及其与内侧颞叶的功能连接。在这里，我们使用功能磁共振成像适应范例报告了 PPC 背侧和腹侧区域之间的分离，以响应自然场景中不同类型的变化。在扫描过程中，受试者执行附带目标检测任务，同时观看试验中独特的顺序呈现的自然场景对，每个场景都包含一个突出的物体。我们观察到顶上回和角回之间存在分离，前者对空间变化表现出更高的敏感性，而后者对场景新颖性表现出更高的敏感性。此外，我们观察到，当受试者观看场景内容发生变化时，海马旁皮层与角回的功能连接增加，但与顶上回的功能连接没有增加。我们的研究结果为 PPC 背侧和腹侧区域之间的分离提供了支持，并表明背侧 PPC 可能支持视觉环境的空间编码，即使这些信息与手头的任务无关。此外，通过揭示 SPG 和 AG 与 MTL 的不同功能相互作用，我们的结果有助于加深我们对 MTL 和 PPC 如何合作更新我们周围世界的表征的理解。
The posterior parietal cortex (PPC) is thought to interact with the medial temporal lobe (MTL) to support spatial cognition and topographical memory. While the response of medial temporal lobe regions to topographical stimuli has been intensively studied, much less research has focused on the role of PPC and its functional connectivity with the medial temporal lobe. Here we report a dissociation between dorsal and ventral regions of PPC in response to different types of change in natural scenes using an fMRI adaptation paradigm. During scanning subjects performed an incidental target detection task whilst viewing trial unique sequentially presented pairs of natural scenes, each containing a single prominent object. We observed a dissociation between the superior parietal gyrus and the angular gyrus, with the former showing greater sensitivity to spatial change, and the latter showing greater sensitivity to scene novelty. In addition, we observed that the parahippocampal cortex has increased functional connectivity with the angular gyrus, but not superior parietal gyrus, when subjects view change to the scene content. Our findings provide support for proposed dissociations between dorsal and ventral regions of PPC and suggest that the dorsal PPC may support the spatial coding of the visual environment even when this information is incidental to the task at hand. Further, through revealing the differential functional interactions of the SPG and AG with the MTL our results help advance our understanding of how the MTL and PPC cooperate to update representations of the world around us.
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影响因子：
2.6
作者：
Dobbins IG;Jaeger A;Studer B;Simons JS
通讯作者：
Simons JS
DOI：
10.1523/jneurosci.6021-09.2010
发表时间：
2010-05-26
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Brown TI;Ross RS;Keller JB;Hasselmo ME;Stern CE
通讯作者：
Stern CE
影响因子：
19.9
作者：
Epstein, Russell A.
通讯作者：
Epstein, Russell A.
影响因子：
64.8
作者：
Epstein, R;Kanwisher, N
通讯作者：
Kanwisher, N
影响因子：
3.7
作者：
Constantinidis, C;Steinmetz, MA
通讯作者：
Steinmetz, MA