Characteristics and patterns of pediatric chemotherapy-induced peripheral neuropathy: A systematic review.
Characteristics and patterns of pediatric chemotherapy-induced peripheral neuropathy: A systematic review.
复制标题
儿科化疗引起的周围神经病变的特征和模式：系统评价。
DOI：
10.1016/j.ctarc.2021.100420
复制
发表时间：
2021
影响因子：
--
通讯作者：
ToxicNeuropathyConsortiumofthePeripheralNerveSociety
中科院分区：
文献类型：
--
作者：
Smith,EllenMLavoie;Kuisell,Clare;Cho,Youmin;Kanzawa-Lee,GraceA;Gilchrist,LauraS;Park,SusannaB;Scott,MaryR;Alberti,Paola;ToxicNeuropathyConsortiumofthePeripheralNerveSociety
本系统综述提供了一个高质量的综合经验证据化疗诱导的周围神经病变（CIPN）的特点和模式中描述的儿童接受神经毒性化疗治疗癌症的研究。检索了PubMed、CINAHL、PsycINFO和Embase中2009-2019年发表的文章，共获得861篇。42篇论文符合合格标准，其中31篇描述了长春新碱诱导的CIPN的特征和模式。57%的文章质量低至中等;测量缺陷是最常见的限制。报告的CIPN发生率变化很大（2.8%-100%），这取决于风险因素（例如，种族）和测量方法。感觉、运动、自主神经CIPN和疼痛的发生率分别为12- 28%、50- 72%、0.8-83%和5.7- 44%。证据表明，感觉和运动神经病变、疼痛和功能缺陷是常见的，并且可以持续到成年。白种人是一个危险因素，与先前的想法相反，累积化疗剂量本身并不能预测CIPN的严重程度。其他风险因素的影响尚不清楚，迄今为止的研究尚未探讨种族，遗传，年龄，性别，药物代谢和营养状况等因素之间的潜在相互作用。
This systematic review provides a high-quality synthesis of the empirical evidence regarding chemotherapy-induced peripheral neuropathy (CIPN) characteristics and patterns described in studies of children who received neurotoxic chemotherapy to treat cancer. PubMed, CINAHL, PsycINFO, and Embase were searched for articles published 2009-2019, yielding 861. Forty-two papers met the eligibility criteria, including 31 that described characteristics and patterns of vincristine-induced CIPN. Fifty-seven percent of articles were of low to moderate quality; measurement flaws were the most common limitations. The reported CIPN incidence varies widely (2.8%–100%) depending on risk factors (e.g., race) and the measurement approach. Incidence rates of sensory, motor, autonomic CIPN, and pain were 12-28%, 50-72%, 0.8-83% and 5.7-44%, respectively. The evidence suggests that sensory and motor neuropathy, pain, and functional deficits are common and can persist into adulthood. Caucasian race is a risk factor and, contrary to prior thinking, cumulative chemotherapy dosage alone does not predict CIPN severity. The influence of other risk factors is less clear, and studies to date have not explored potential interactions among race, genetics, age, sex, drug metabolism, and nutritional status, among other factors.
登录
查看更多内容
乙舒酰亚胺和丙戊酸盐在治疗癫痫中的用途。
影响因子：
2.4
作者：
Sheila J. Wallace
通讯作者：
Sheila J. Wallace
丙戊酸具有直接肝毒性作用。
DOI：
--
发表时间：
1979
期刊：
Journal of the American Medical Association (JAMA)
影响因子：
--
作者：
N. Sussman;L. W. McLain
通讯作者：
L. W. McLain
影响因子：
158.5
作者：
KOCHWESER, J;BROWNE, TR
通讯作者：
BROWNE, TR
影响因子：
5.6
作者：
JEAVONS, PM
通讯作者：
JEAVONS, PM
丙戊酸钠和其他抗惊厥药对大鼠肝细胞培养物的肝毒性
影响因子：
5.6
作者：
E. Kingsley;R. Tweedale;K. G. Tolman
通讯作者：
K. G. Tolman