Circulating cytokines as biomarkers of alcohol abuse and alcoholism.
Circulating cytokines as biomarkers of alcohol abuse and alcoholism.
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DOI：
10.1007/s11481-009-9185-z
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发表时间：
2010-03
影响因子：
6.2
通讯作者：
Vrana, Kent E.
中科院分区：
文献类型：
--
作者：
Achur, Rajeshwara N.;Freeman, Willard M.;Vrana, Kent E.
目前还没有一致的客观生化指标的酒精滥用和酒精中毒。开发可靠的诊断生物标志物，允许准确评估酒精摄入量和饮酒模式，对治疗和研究领域至关重要。在其他疾病中的诊断生物标志物的开发已经证明了开放的系统生物学、生物标志物的筛选和对特定生物分子或生物分子家族的更合理的集中努力的效用。长期饮酒会导致炎症细胞和适应性免疫反应的改变，并伴有相关的病理学和感染发生率增加。这使得研究人员将注意力集中在识别酒精滥用模型中的细胞因子生物标志物上。已知酒精会改变血浆和各种组织中的细胞因子水平，包括肺、肝，以及非常重要的脑。已经鉴定了许多细胞因子生物标志物候选物，包括：TNF α、IL 1-α、IL 1-β、IL 6、IL 8、IL 12和MCP-1。这是一个新兴的和潜在的令人兴奋的研究途径，因为循环细胞因子可能有助于诊断生物标志物面板和多种生物标志物的组合可以显着增加生化测试的灵敏度和特异性，帮助可靠和准确地检测过量酒精摄入。
There are currently no consistent objective biochemical markers of alcohol abuse and alcoholism. Development of reliable diagnostic biomarkers that permit accurate assessment of alcohol intake and patterns of drinking is of prime importance to treatment and research fields. Diagnostic biomarker development in other diseases has demonstrated the utility of both open, systems biology, screening for biomarkers and more rational focused efforts on specific biomolecules or families of biomolecules. Long term alcohol consumption leads to altered inflammatory cell and adaptive immune responses with associated pathologies and increased incidence of infections. This has led researchers to focus attention on identifying cytokine biomarkers in models of alcohol abuse. Alcohol is known to alter cytokine levels in plasma and a variety of tissues including lung, liver, and very importantly brain. A number of cytokine biomarker candidates have been identified, including: TNF alpha, IL1-alpha, IL1-beta, IL6, IL8, IL12 and MCP-1. This is an emerging and potentially exciting avenue of research in that circulating cytokines may contribute to diagnostic biomarker panels and a combination of multiple biomarkers may significantly increase the sensitivity and specificity of the biochemical tests aiding reliable and accurate detection of excessive alcohol intake.
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DOI：
10.1097/01.alc.0000023986.42254.f5
发表时间：
2002-08-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Anton, RF;Lieber, C;Tabakoff, B
通讯作者：
Tabakoff, B
DOI：
10.3988/jcn.2008.4.2.84
发表时间：
2008-06
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
--
作者：
Choi C;Jeong JH;Jang JS;Choi K;Lee J;Kwon J;Choi KG;Lee JS;Kang SW
通讯作者：
Kang SW
DOI：
10.1111/j.1530-0277.2000.tb00012.x
发表时间：
2000-04-01
影响因子：
3.2
作者：
Fujimoto, M;Uemura, M;Fukui, H
通讯作者：
Fukui, H
影响因子：
4.7
作者：
Díaz, LE;Montero, A;Marcos, A
通讯作者：
Marcos, A
影响因子：
--
作者：
Bush, K;Kivlahan, DR;Bradley, KA
通讯作者：
Bradley, KA