The interindividual variability of multimodal brain connectivity maintains spatial heterogeneity and relates to tissue microstructure.
The interindividual variability of multimodal brain connectivity maintains spatial heterogeneity and relates to tissue microstructure.
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DOI：
10.1038/s42003-022-03974-w
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发表时间：
2022-09-23
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
人类在生物识别方面存在很大差异，但个体之间的大脑连接性在多大程度上存在差异仍然是未知的。通过结合弥散加权成像（DWI）和脑磁图（MEG），本研究表征了多模态脑连接的受试者间变异性（ISV）。结构连接的特点是在包括核心多需求网络在内的联合皮层中具有较高的ISV，而在感觉运动皮层中具有较低的ISV。MEG ISV具有频率依赖性特征，并且MEG ISV的程度与选择性宏观皮质簇的结构连接性ISV的程度一致。在整个皮质，结构连接和β-带MEG功能连接的ISV与皮质髓鞘含量呈负相关，皮质髓鞘含量由高分辨率7 T MRI测量的定量T1弛豫率指数化。此外，MEG ISV从α到γ波段与DWI微结构模型估计的白质组织的阻碍和限制有关。我们的研究结果描绘了多种形式的大脑连接的ISV之间的相互关系，并强调了支持ISV的组织微结构的作用。多模态成像方法突出了组织微观结构在连接体个体间变异性中的作用
Humans differ from each other in a wide range of biometrics, but to what extent brain connectivity varies between individuals remains largely unknown. By combining diffusion-weighted imaging (DWI) and magnetoencephalography (MEG), this study characterizes the inter-subject variability (ISV) of multimodal brain connectivity. Structural connectivity is characterized by higher ISV in association cortices including the core multiple-demand network and lower ISV in the sensorimotor cortex. MEG ISV exhibits frequency-dependent signatures, and the extent of MEG ISV is consistent with that of structural connectivity ISV in selective macroscopic cortical clusters. Across the cortex, the ISVs of structural connectivity and beta-band MEG functional connectivity are negatively associated with cortical myelin content indexed by the quantitative T1 relaxation rate measured by high-resolution 7 T MRI. Furthermore, MEG ISV from alpha to gamma bands relates to the hindrance and restriction of the white-matter tissue estimated by DWI microstructural models. Our findings depict the inter-relationship between the ISV of brain connectivity from multiple modalities, and highlight the role of tissue microstructure underpinning the ISV. A multimodal imaging approach highlights the role of tissue microstructure underpinning the inter-individual variability in the connectome
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
影响因子：
5.7
作者：
Colclough GL;Woolrich MW;Tewarie PK;Brookes MJ;Quinn AJ;Smith SM
通讯作者：
Smith SM
DOI：
10.1073/pnas.1010356107
发表时间：
2010-09-07
影响因子：
11.1
作者：
Collins, Christine E.;Airey, David C.;Kaas, Jon H.
通讯作者：
Kaas, Jon H.
影响因子：
3.7
作者：
Fjell, Anders M.;Westlye, Lars T.;Walhovd, Kristine B.
通讯作者：
Walhovd, Kristine B.
DOI：
10.1523/jneurosci.4682-09.2010
发表时间：
2010-02-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hill J;Dierker D;Neil J;Inder T;Knutsen A;Harwell J;Coalson T;Van Essen D
通讯作者：
Van Essen D