Sleep duration and resting fMRI functional connectivity: examination of short sleepers with and without perceived daytime dysfunction.
Sleep duration and resting fMRI functional connectivity: examination of short sleepers with and without perceived daytime dysfunction.
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DOI：
10.1002/brb3.576
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发表时间：
2016-12
影响因子：
3.1
通讯作者：
Anderson, Jeffrey S.
中科院分区：
文献类型：
--
作者：
Curtis, Brian J.;Williams, Paula G.;Jones, Christopher R.;Anderson, Jeffrey S.
大约30%的美国人报告经常性的睡眠不足;然而，个人之间的睡眠需求差异很大。一些“习惯性短睡眠者”通常每晚睡4-6小时，没有自我报告的不良后果。识别感知睡眠相关功能障碍的个体差异背后的神经机制对于理解睡眠持续时间与健康之间的关联具有重要意义。这项研究利用了来自人类连接组项目的839名受试者的数据，以检查静息功能连接与自我报告的短睡眠时间的相关性，以及短睡眠者与无功能障碍者之间的差异。功能连接分析使用包裹覆盖皮质，皮质下，和小脑灰质在5毫米分辨率。自我报告的睡眠持续时间可预测静息功能连接中受试者间差异的主要模式之一。与传统睡眠者相比，这两种短睡眠者亚型都表现出与觉醒减少一致的静息fMRI（R-fMRI）特征，这可能表明否认功能障碍的人对功能的感知不准确。否认功能障碍的短睡眠者表现出感觉皮层与双侧杏仁核和海马体之间的连接增加，这表明有效的睡眠相关记忆巩固可能部分解释了感知白天功能障碍的个体差异。总体而言，目前的研究结果表明，R-fMRI研究应包括对前一个月平均睡眠时间的评估。此外，短睡眠者亚型的研究结果提供了一个候选的神经机制的差异，感知白天的损害与短睡眠时间。
Approximately 30% of the U.S. population reports recurrent short sleep; however, perceived sleep need varies widely among individuals. Some “habitual short sleepers” routinely sleep 4–6 hr/night without self‐reported adverse consequences. Identifying neural mechanisms underlying individual differences in perceived sleep‐related dysfunction has important implications for understanding associations between sleep duration and health. This study utilized data from 839 subjects of the Human Connectome Project to examine resting functional connectivity associations with self‐reported short sleep duration, as well as differences between short sleepers with versus without reported dysfunction. Functional connectivity was analyzed using a parcellation covering the cortical, subcortical, and cerebellar gray matter at 5 mm resolution. Self‐reported sleep duration predicts one of the primary patterns of intersubject variance in resting functional connectivity. Compared to conventional sleepers, both short sleeper subtypes exhibited resting fMRI (R‐fMRI) signatures consistent with diminished wakefulness, potentially indicating inaccurate perception of functionality among those denying dysfunction. Short sleepers denying dysfunction exhibited increased connectivity between sensory cortices and bilateral amygdala and hippocampus, suggesting that efficient sleep‐related memory consolidation may partly explain individual differences in perceived daytime dysfunction. Overall, current findings indicate that R‐fMRI investigations should include assessment of average sleep duration during the prior month. Furthermore, short sleeper subtype findings provide a candidate neural mechanism underlying differences in perceived daytime impairment associated with short sleep duration.
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影响因子：
17.1
作者：
Cohen DA;Wang W;Wyatt JK;Kronauer RE;Dijk DJ;Czeisler CA;Klerman EB
通讯作者：
Klerman EB
影响因子：
3.7
作者：
Duggan KA;Friedman HS;McDevitt EA;Mednick SC
通讯作者：
Mednick SC
影响因子：
4.1
作者：
Hirshkowitz, Max;Whiton, Kaitlyn;Hillard, Paula J. Adams
通讯作者：
Hillard, Paula J. Adams
影响因子：
5.6
作者：
Ertel, Karen A.;Berkman, Lisa F.;Buxton, Orfeu M.
通讯作者：
Buxton, Orfeu M.
影响因子：
4.4
作者：
Johns, MW
通讯作者：
Johns, MW