A National Study of Survival Trends and Conditional Survival in Nasopharyngeal Carcinoma: Analysis of the National Population-Based Surveillance Epidemiology and End Results Registry.
A National Study of Survival Trends and Conditional Survival in Nasopharyngeal Carcinoma: Analysis of the National Population-Based Surveillance Epidemiology and End Results Registry.
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鼻咽癌生存趋势和条件生存的全国研究：全国人群监测流行病学和最终结果登记分析
DOI：
10.4143/crt.2016.544
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发表时间：
2018-04
影响因子：
4.6
通讯作者：
Sun Y
中科院分区：
文献类型：
--
作者：
Lv JW;Huang XD;Chen YP;Zhou GQ;Tang LL;Mao YP;Li WF;Lin AH;Ma J;Sun Y
目的条件生存率（Conditional survival，CS）是诊断后一段时间内生存的重要信息.目前，关于鼻咽癌（NPC）患者CS模式的信息还很缺乏。我们的目的是分析生存率随着时间的推移，并估计CS的NPC患者使用全国人口为基础的登记。材料与方法从监测流行病学最终结果登记处确定1973年至2007年诊断为NPC并至少随访5年的患者。采用Kaplan-Meier分析计算传统生存率和粗CS估计值。使用正确的组预后方法，根据比例风险模型绘制风险调整的生存曲线。结果登记处。采用Kaplan-Meier分析计算传统生存率和粗CS估计值。使用正确的组预后方法，根据比例风险模型绘制风险调整的生存曲线。结果在分析的7,713例患者中，校正的基线5年总生存率从1973-1979年的36.0%、1980-1989年的41.7%、1990-1999年的46.6%显著提高到2000-2007年的54.7%（p < 0.01）。CS分析表明，每多存活一年，未来5年的校正生存概率从诊断时的66.7%（局部）、54.0%（区域）和35.3%（远处）增加到存活5年的患者的83.7%（局部）、75.0%（区域）和62.2%（远处）。校正后的5年CS最初在年龄、性别、肿瘤组织学、种族和分期亚组之间存在差异，但随着时间的推移而收敛。结论鼻咽癌患者的治疗效果在过去的几十年里得到了很大的改善。随着患者生存时间的延长，CS的增加在远处疾病患者中比在局部或区域性疾病患者中更加突出。CS为诊断后存活一段时间的患者提供了更动态的预后信息。
Purpose Conditional survival (CS) provides important information on survival for a period of time after diagnosis. Currently, information on CS patterns of patients with nasopharyngeal carcinoma (NPC) is lacking. We aimed to analyze survival rate over time and estimate CS for NPC patients using a national population-based registry. Materials and Methods Patients diagnosed with NPC between 1973 and 2007 with at least 5-year follow-up were identified from the Surveillance Epidemiology End Results registry. Traditional survival rates and crude CS estimateswere calculated using Kaplan-Meier analysis. Risk-adjusted survival curves were plotted from the proportional hazards model using the correct group prognosis method. Results registry. Traditional survival rates and crude CS estimateswere calculated using Kaplan-Meier analysis. Risk-adjusted survival curves were plotted from the proportional hazards model using the correct group prognosis method. Results For 7,713 patients analyzed, adjusted baseline 5-year overall survival improved significantly from 36.0% in patients diagnosed in 1973-1979, 41.7% in 1980-1989, 46.6% in 1990-1999, to 54.7% in 2000-2007 (p < 0.01). CS analysis demonstrated that for every additional year survived, adjusted probability of surviving the next 5 years increased from 66.7% (localized), 54.0% (regional), and 35.3% (distant) at the time of diagnosis, to 83.7% (localized), 75.0% (regional), and 62.2% (distant) for patients who had survived 5 years. Adjusted 5-year CS differed among age, sex, tumor histology, ethnicity, and stage subgroups initially, but converged with time. Conclusion Treatment outcomes of NPC patients have greatly improved over the decades. Increases in CS become more prominent in patients with distant disease than in those with localized or regional disease as patients survive longer. CS provides more dynamic prognostic information for patients who have survived a period of time after diagnosis.
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影响因子：
7.4
作者：
Wang, Samuel J.;Emery, Rachel;Thomas, Charles R., Jr.
通讯作者：
Thomas, Charles R., Jr.
影响因子：
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影响因子：
10.3
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50.5
作者：
Ou, S. -H. I.;Zell, J. A.;Anton-Culver, H.
通讯作者：
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