The evolution and functional repertoire of translation proteins following the origin of life.
The evolution and functional repertoire of translation proteins following the origin of life.
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DOI：
10.1186/1745-6150-5-15
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发表时间：
2010-04-08
期刊：
影响因子：
5.5
通讯作者：
Baross JA
中科院分区：
文献类型：
--
作者：
Goldman AD;Samudrala R;Baross JA
RNA世界假说认为，最早的遗传系统由信息RNA分子组成，这些分子指导适度功能的RNA分子的合成。进一步的证据表明，正是在这种基于 RNA 的遗传系统中，生命发展出了通过翻译遗传密码来合成蛋白质的能力。在这里，我们通过与现代翻译相关的蛋白质结构的进化调查来研究翻译系统的早期发展。我们的分析揭示了翻译蛋白的结构扩展紧随RNA世界之后、远早于DNA基因组的建立。随后的功能注释表明，十种最古老的蛋白质结构的代表负责现代翻译中发现的所有核心蛋白质功能。我们认为，这种早期强大的翻译系统是凭借正反馈循环而进化的，在该循环中，该系统能够创造出越来越复杂的蛋白质，以进一步增强其自身的功能。本文由 Janet Siefert、George Fox 和 Antonio Lazcano（由 Laura Landweber 提名）审阅
The RNA world hypothesis posits that the earliest genetic system consisted of informational RNA molecules that directed the synthesis of modestly functional RNA molecules. Further evidence suggests that it was within this RNA-based genetic system that life developed the ability to synthesize proteins by translating genetic code. Here we investigate the early development of the translation system through an evolutionary survey of protein architectures associated with modern translation. Our analysis reveals a structural expansion of translation proteins immediately following the RNA world and well before the establishment of the DNA genome. Subsequent functional annotation shows that representatives of the ten most ancestral protein architectures are responsible for all of the core protein functions found in modern translation. We propose that this early robust translation system evolved by virtue of a positive feedback cycle in which the system was able to create increasingly complex proteins to further enhance its own function. This article was reviewed by Janet Siefert, George Fox, and Antonio Lazcano (nominated by Laura Landweber)
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