The correctability of the nutritional, immune, and hematopoietic manifestations of protein calorie malnutrition in the elderly.
The correctability of the nutritional, immune, and hematopoietic manifestations of protein calorie malnutrition in the elderly.
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老年人蛋白质热量营养不良的营养、免疫和造血表现的可纠正性。
DOI：
10.1080/07315724.1982.10718069
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发表时间：
1982
影响因子：
3.5
通讯作者：
Mitchell,CO
中科院分区：
文献类型：
--
作者：
Lipschitz,DA;Mitchell,CO
蛋白质热量营养不良在住院患者中的发生率更高。本报告描述了9例年龄在73~95岁之间的老年营养不良患者的临床表现和对营养治疗的反应。营养不良的临床特征包括体重减轻、意识模糊、低白蛋白血症（平均2.8 gm/dl）、低总铁结合力（TIBC）（平均192微克/dl）、无反应性、淋巴细胞减少（平均1 × 10（3）个细胞/微升）和贫血（平均9.0 gm/dl）。我们的研究对象被跟踪了42天。在两个，高营养是通过自愿的食物摄入和聚合物膳食补充剂。7例患者需要通过鼻胃管喂养21天。三周后，体重增加，意识模糊减少，食欲和活动能力改善，血清白蛋白和TIBC显著增加。当时，无受试者出现过敏反应，淋巴细胞计数显著增加。观察到血清铁和饱和度百分比增加，到第42天，血红蛋白显著升高。作为干细胞功能的测量，在营养支持21天之前和之后，对4名受试者的定向粒细胞/巨噬细胞祖细胞（CFU-C）进行定量。CFU-C数量从平均0.1 × 107个/kg显著增加至正常值0.85 × 107个/kg。因此，除了纠正营养不足外，高营养还使免疫和造血异常恢复到接近正常水平。虽然改善可能反映了从相关疾病中恢复，但营养不良的纠正也可能是这种反应的原因，营养不良是这些免疫和造血异常的公认原因。这些观察结果强调了认识老年人营养不良的重要性，并强调了在将血液学和免疫学异常归因于衰老过程之前进行仔细营养评估的必要性。
Protein calorie malnutrition is being recognized with greater frequency in the hospitalized patient. This report describes the clinical presentation and response to nutritional therapy in nine elderly malnourished patients ranging from 73 to 95 years. Clinical features of malnutrition include weight loss, confusion, hypoalbuminemia (mean 2.8 gm/dl), a low total iron binding capacity (TIBC) (mean 192 micrograms/dl), anergy, lymphocytopenia (mean 1 × 10(3) cells/microliter) and an anemia (mean 9.0 gm/dl). Our subjects were followed for 42 days. In two, hyperalimentation was achieved by voluntary food intake and polymeric dietary supplements. In seven, feeding for 21 days via nasogastric tube was required. After three weeks, weight gain, decreased confusion, improved appetite and mobility, and significant increases in serum albumin and TIBC were seen. At that time, no subject was anergic and lymphocyte counts increased significantly. Increase in the serum iron and percent saturation was noted, and by day 42, a significant elevation in the hemoglobin occurred. As a measure of stem cell function, the committed granulocyte/macrophage progenitor cell (CFU-C) was quantitated in four subjects prior to and following 21 days of nutritional support. A marked increase in CFU-C number from a mean of 0.1 × 10(7) cells/kg to a normal value of 0.85 × 10(7) cells/kg was seen. Thus in addition to correcting the nutritional deficit, hyperalimentation returned immune and hematopoietic abnormalities to near normal levels. While improvement could reflect recovery from an associated disease, it is just as likely that correction of malnutrition, a well-recognized cause of these immunologic and hematopoietic abnormalities, accounted for the response. These observations emphasize the importance of recognizing malnutrition in the elderly and highlight the need for a careful nutritional assessment prior to ascribing hematologic and immunologic abnormalities to the aging process.
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老年人淋巴细胞功能受损。
影响因子：
15.9
作者：
M. Weksler;T. Hütteroth
通讯作者：
T. Hütteroth
DOI：
10.1159/000244707
发表时间：
1962
期刊：
Gerontologia clinica
影响因子：
--
作者：
M. Timaffy
通讯作者：
M. Timaffy
影响因子：
2.9
作者：
MILES, LEM;LIPSCHITZ, DA;COOK, JD
通讯作者：
COOK, JD
营养不良、体液免疫和感染
DOI：
10.1007/bf02894341
发表时间：
1976
期刊：
The Indian Journal of Pediatrics
影响因子：
--
作者：
R. Chandra;S. Chakraburty;S. Chandra
通讯作者：
S. Chandra
恒河猴实验性蛋白质缺乏症贫血，特别是铁代谢。
影响因子：
20.3
作者：
S. Sood;M. Deo;V. Ramalingaswami
通讯作者：
V. Ramalingaswami