Lipophilic micronutrients and adipose tissue biology.

Lipophilic micronutrients and adipose tissue biology.
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DOI:
10.3390/nu4111622
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发表时间:
2012-11-06
期刊:
影响因子:
5.9
通讯作者:
Tourniaire F
Tourniaire F
中科院分区:
医学2区
文献类型:
--
作者:
Landrier JF;Marcotorchino J;Tourniaire F

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亲脂性微量营养素(LM)构成了包括几种维生素(A、D、E、K)和类胡萝卜素的大分子家族。它们调节基因表达的能力正变得越来越清楚,并构成营养基因组学的重要组成部分。有趣的是,脂肪组织不仅是这些分子在体内的主要储存部位,而且还受到LM的调节作用。事实上,在脂肪组织中已经描述了几种基因调控,这些基因调控可能强烈影响其在脂肪形成、炎症状态或能量稳态和代谢等调节方面的生物学。在肥胖症和相关病理学的背景下,这种规定对健康影响的影响代表了一个令人兴奋的新兴研究领域。目前的审查将集中在调节作用的维生素A,D,E和K以及类胡萝卜素对脂肪组织的生物学和生理学,特别是在肥胖症和相关疾病的背景下。
Lipophilic micronutrients (LM) constitute a large family of molecules including several vitamins (A, D, E, K) and carotenoids. Their ability to regulate gene expression is becoming increasingly clear and constitutes an important part of nutrigenomics. Interestingly, adipose tissue is not only a main storage site for these molecules within the body, but it is also subjected to the regulatory effects of LM. Indeed, several gene regulations have been described in adipose tissue that could strongly impact its biology with respect to the modulation of adipogenesis, inflammatory status, or energy homeostasis and metabolism, among others. The repercussions in terms of health effects of such regulations in the context of obesity and associated pathologies represent an exciting and emerging field of research. The present review will focus on the regulatory effects of vitamin A, D, E and K as well as carotenoids on adipose tissue biology and physiology, notably in the context of obesity and associated disorders.
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