Identify Distinct Prognostic Impact of ALDH1 Family Members by TCGA Database in Acute Myeloid Leukemia
Identify Distinct Prognostic Impact of ALDH1 Family Members by TCGA Database in Acute Myeloid Leukemia
复制标题
通过 TCGA 数据库确定 ALDH1 家族成员对急性髓系白血病的独特预后影响
DOI：
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Su Yi
中科院分区：
文献类型：
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作者：
Yi Hai;Deng Rui;Fan Fangyi;Sun Haoping;He Guangcui;Lai Sihan;Su Yi
背景：急性髓系白血病是一种异质性疾病。确定预后的生物标志物是重要的指导分层和治疗策略。方法：应用肿瘤基因组图谱（TCGA）数据库检测ALDH 1家族各成员在AML中的表达水平及其对预后的影响。结果：168例患者中ALDH 1家族成员表达水平均为阳性。我们发现ALDH1A1水平与AML的预后相关，但在其他ALDH1成员中不相关。此外，我们从TCGA数据库中获得了160例AML患者的生存数据。我们发现ALDH1A1高表达与总生存期（OS）差相关，主要发生在FLT3突变组。在FLT3野生型人群中，ALDH1A2高表达与OS差显著相关，但在FLT3突变组中不相关。在FLT3突变组中ALDH1A3高表达与OS差显著相关，但在FLT3野生型组中不相关。ALDH1B1、ALDH1L1和ALDH1L2水平与AML患者的OS无相关性。结论：ALDH 1家族成员对预后的影响不同，有待进一步研究。
Background: Acute myeloid leukemia is a heterogeneous disease. Identify the prognostic biomarker is important to guide stratifcation and therapeutic.strategies. Method: We detected the expression level and the prognostic impact of each ALDH1 family members in AML by The Cancer Genome Atlas (TCGA) database. Results: Upon 168 patients whose expression level of ALDH1 family members were available. We found that the level of ALDH1A1 correlated to the prognosis of AML by the National Comprehensive Cancer Network (NCCN) stratifcation but not in other ALDH1 members. Moreover, we got survival data from 160 AML patients in TCGA database. We found that high ALDH1A1 expression correlated to poor Overall Survival (OS), mostly in Fms-like Tyrosine Kinase-3 (FLT3) mutated group. HighALDH1A2 expression signifcantly correlated to poor OS in FLT3 wild type population but not in FLT3 mutated group. High ALDH1A3 expression signifcantly correlated to poor OS in FLT3 mutated group but not in FLT3 wild type group. There was no relationship between the OS of AML with the level of ALDH1B1, ALDH1L1 and ALDH1L2. Conclusion: The prognostic impacts were different in each ALDH1 family members, which needs further investigation.
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影响因子：
12.8
作者：
Venton G;Pérez-Alea M;Baier C;Fournet G;Quash G;Labiad Y;Martin G;Sanderson F;Poullin P;Suchon P;Farnault L;Nguyen C;Brunet C;Ceylan I;Costello RT
通讯作者：
Costello RT
影响因子：
3.8
作者：
Flahaut M;Jauquier N;Chevalier N;Nardou K;Balmas Bourloud K;Joseph JM;Barras D;Widmann C;Gross N;Renella R;Mühlethaler-Mottet A
通讯作者：
Mühlethaler-Mottet A
影响因子：
8.8
作者：
Tan EY;Thike AA;Breast Surgical Team at Outram;Tan PH
通讯作者：
Tan PH
影响因子：
--
作者：
Shaokun Wu;W. Xue;Xiaobo Huang;Xiaoli Yu;M. Luo;Ying Huang;Yimin Liu;Z. Bi;X. Qiu;S. Bai
通讯作者：
Shaokun Wu;W. Xue;Xiaobo Huang;Xiaoli Yu;M. Luo;Ying Huang;Yimin Liu;Z. Bi;X. Qiu;S. Bai
影响因子：
11.4
作者：
Cheung, A. M. S.;Wan, T. S. K.;Leung, A. Y. H.
通讯作者：
Leung, A. Y. H.