Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees.
Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees.
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DOI：
10.1016/j.joca.2012.09.008
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发表时间：
2013-01
影响因子：
7
通讯作者：
Li, X.
中科院分区：
文献类型：
--
作者：
Kazakia, G. J.;Kuo, D.;Schooler, J.;Siddiqui, S.;Shanbhag, S.;Bernstein, G.;Horvai, A.;Majumdar, S.;Ries, M.;Li, X.
我们的目标是了解在骨性关节炎(OA)进展过程中连接软骨、骨和骨髓变化的生物和力学途径。本研究的目的是评估与膝骨性关节炎相关的骨髓水肿样病变(BMEL)区域内的骨结构和成分。取自10例膝关节骨性关节炎患者的胫骨平台标本(n=18)。磁共振(MR)成像用于识别BMEL并量化软骨成分。采用显微计算机断层扫描(μCT)和高分辨率外周定量计算机断层扫描(HR-PQCT)对软骨下松质骨的密度和微观结构进行定量。用傅里叶变换红外光谱(FTIR)对组织成分进行定量。BMEL内的骨小梁体积分数较高，骨小梁较多且较厚，与未受影响区域相比，骨小梁结构更呈板状。BMEL骨小梁组织成分降低了磷酸盐和碳酸盐含量。可见骨胶原纤维网络的骨髓浸润和骨改建增加的证据。结构和成分的变化特别局限于软骨退化下的区域。这些结果支持骨、骨髓和软骨在膝骨性关节炎进展过程中局部相互作用的范例。定量评估组织的变化和相互作用可能有助于了解疾病的病理生理学，并为疾病的进展提供成像标记物。
Our objective is to understand the biological and mechanical pathways linking cartilage, bone, and marrow changes in the progression of osteoarthritis (OA). The aim of the present study was to evaluate bone structure and composition within bone marrow edema-like lesion (BMEL) regions associated with knee OA. Tibial plateau specimens (n = 18) were collected from 10 subjects with knee OA scheduled for total knee arthroplasty (TKA). Magnetic resonance (MR) imaging was used to identify BMEL and quantify metrics of cartilage composition. Micro-computed tomography (μCT) and high-resolution peripheral quantitative computed tomography (HR-pQCT) were used to quantify density and microstructure of the subchondral trabecular bone. Fourier transform infrared (FTIR) spectroscopy was used to quantify tissue composition. Trabecular bone within BMEL was higher in volume fraction, with more and thicker trabeculae that were more plate-like in structure compared to unaffected regions. BMEL trabecular tissue composition had decreased phosphate and carbonate content. Marrow infiltration by a fibrous collagen network and evidence of increased bone remodeling were present. Structural and compositional changes were specifically localized to regions underlying cartilage degradation. These results support the paradigm of focal interactions among bone, marrow, and cartilage in the progression of knee OA. Quantitative evaluation of tissue changes and interactions may aid in the understanding of disease pathophysiology and provide imaging markers for disease progression.
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影响因子：
10.9
作者：
Carballido-Gamio, Julio;Bauer, Jan S.;Majumdar, Sharmila
通讯作者：
Majumdar, Sharmila
影响因子：
--
作者：
Hunter, David J.;Zhang, Yuqing;Felson, David T.
通讯作者：
Felson, David T.
DOI：
10.1302/0301-620x.85b6.12595
发表时间：
2003-08-01
影响因子：
--
作者：
Ding, M;Odgaard, A;Hvid, I
通讯作者：
Hvid, I
影响因子：
4.2
作者：
Brown, SJ;Pollintine, P;Sharp, CA
通讯作者：
Sharp, CA
影响因子：
4.2
作者：
Courtland, Hayden-William;Nasser, Philip;Goldstone, Andrew B.;Spevak, Lyudmila;Boskey, Adele L.;Jepsen, Karl J.
通讯作者：
Jepsen, Karl J.