Rogue Waves: A Unifying Model of Human Seizure Propagation.
Rogue Waves: A Unifying Model of Human Seizure Propagation.
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DOI：
10.1177/15357597231176345
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发表时间：
2023-07
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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作者：
人类癫痫发作期间快速行波的多种来源：解决争议 Schlafly ED、Marshall FA、Merricks EM、Eden UT、Cash SS、Schevon CA、Kramer MA。神经科学杂志。 2022；42(36):6966-6982。 doi:10.1523/JNEUROSCI.0338-22.2022 在人类癫痫发作期间，有组织的电压活动波迅速席卷大脑皮层。两种相互矛盾的理论描述了这些快速行波的来源：缓慢前进的多单元活动狭窄区域（发作波前）或固定的皮质位置。有限的观察和不同的分析阻碍了这些不相容的理论的解决。在这里，我们通过结合先前人体研究的方法和微电极阵列记录（N = 11 名患者，2 名女性，N = 31 次癫痫发作）来分析行波源，来解决这一分歧。我们发现，与两种现有理论不一致的是，发作期波前和行波之间存在短暂关系，并且在许多癫痫发作中行波有多个稳定方向。使用结合了两种现有理论要素的计算模型，我们证明了发作波前和固定源之间的相互作用再现了体内观察到的行波动力学。我们的结论是，结合两种现有理论可以产生发作行波的多样性。人类癫痫发作期间穿过皮层传播的电压放电的来源仍然未知。存在两种候选理论，每种理论都提出了不同的放电源。对每种理论的支持都包括对少量人类受试者记录的观察，并使用单独开发的方法进行分析。不同的、有限的数据和不同的分析方法如何影响每种理论的证据尚不清楚。为了解决这些差异，我们结合了为每种理论单独收集的独特的人体微电极阵列记录，并使用统一的方法分析这些组合数据。我们表明现有理论都无法充分描述数据。然后，我们提出了一种新理论，该理论统一了现有的建议，并成功地再现了体内观察到的电压放电动力学。
Multiple Sources of Fast Traveling Waves During Human Seizures: Resolving a Controversy Schlafly ED, Marshall FA, Merricks EM, Eden UT, Cash SS, Schevon CA, Kramer MA. J Neurosci. 2022;42(36):6966-6982. doi:10.1523/JNEUROSCI.0338-22.2022 During human seizures organized waves of voltage activity rapidly sweep across the cortex. Two contradictory theories describe the source of these fast traveling waves: either a slowly advancing narrow region of multiunit activity (an ictal wavefront) or a fixed cortical location. Limited observations and different analyses prevent resolution of these incompatible theories. Here we address this disagreement by combining the methods and microelectrode array recordings (N = 11 patients, 2 females, N = 31 seizures) from previous human studies to analyze the traveling wave source. We find—inconsistent with both existing theories—a transient relationship between the ictal wavefront and traveling waves, and multiple stable directions of traveling waves in many seizures. Using a computational model that combines elements of both existing theories, we show that interactions between an ictal wavefront and fixed source reproduce the traveling wave dynamics observed in vivo. We conclude that combining both existing theories can generate the diversity of ictal traveling waves. The source of voltage discharges that propagate across cortex during human seizures remains unknown. Two candidate theories exist, each proposing a different discharge source. Support for each theory consists of observations from a small number of human subject recordings, analyzed with separately developed methods. How the different, limited data and different analysis methods impact the evidence for each theory is unclear. To resolve these differences, we combine the unique, human microelectrode array recordings collected separately for each theory and analyze these combined data with a unified approach. We show that neither existing theory adequately describes the data. We then propose a new theory that unifies existing proposals and successfully reproduces the voltage discharge dynamics observed in vivo.
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影响因子：
16.6
作者：
Martinet LE;Fiddyment G;Madsen JR;Eskandar EN;Truccolo W;Eden UT;Cash SS;Kramer MA
通讯作者：
Kramer MA
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
16.6
作者：
Smith EH;Liou JY;Davis TS;Merricks EM;Kellis SS;Weiss SA;Greger B;House PA;McKhann GM 2nd;Goodman RR;Emerson RG;Bateman LM;Trevelyan AJ;Schevon CA
通讯作者：
Schevon CA
影响因子：
5.3
作者：
Truccolo, Wilson;Ahmed, Omar J.;Cash, Sydney S.
通讯作者：
Cash, Sydney S.
影响因子：
4.6
作者：
Kim TJ;Choi JW;Han M;Kim BG;Park SA;Huh K;Choi JY
通讯作者：
Choi JY