Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident.
Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the Yusho incident.
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DOI：
10.1289/ehp.10686
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发表时间：
2008-05
影响因子：
10.4
通讯作者：
Furue M
中科院分区：
文献类型：
--
作者：
Tsukimori K;Tokunaga S;Shibata S;Uchi H;Nakayama D;Ishimaru T;Nakano H;Wake N;Yoshimura T;Furue M
在动物研究中，母亲暴露于多氯联苯(PCbs)与自然流产和死产比例的增加有关。1968年，在日本，人类意外地接触到被多氯联苯和其他与二恶英相关的化合物(如多氯二苯并呋喃)污染的米油，导致了后来被称为玉树油病的疾病的发展。这项研究的目的是调查玉树妇女中母亲接触多氯联苯和二恶英与不良妊娠结局的关系。2004年，我们采访了214名玉树妇女(512例怀孕)，了解她们在过去36年中的妊娠结局。妊娠结局包括人工流产、自然流产、早产和妊娠丢失。在怀孕年(暴露后10年内)，人工流产[按分娩年龄调整的优势比(ORADJ)=5.93；95%可信区间(CI)2.2 1~15.91；双尾P&t；0.001]和早产(ORADJ=5.70；95%CI，1.17~2 7.79；P=0.0 3)的比例显著高于1958年至1967年(事件发生前10年)的比例。自然流产(ORADJ=2.09；95%CI，0.84~5.18)和妊娠丢失(ORADJ=2.11；95%CI，0.92~4.87)发生率较高(OR=2.18；95%CI，1.02~4.66)，但差异无统计学意义(P=0.11和P=0.08)。我们发现，与1968年之前的妊娠相比，在1978-1987年或1988-2003年期间怀孕的这些不良妊娠结局的比例没有显着增加。高水平的多氯联苯/多氯二苯并呋喃暴露对玉树妇女的妊娠结局有一些不利影响。
Maternal exposure to polychlorinated biphenyls (PCBs) is associated with increased proportions of spontaneous abortion and stillbirth in animal studies. In Japan in 1968, accidental human exposure to rice oil contaminated with PCBs and other dioxin-related compounds, such as polychlorinated dibenzofurans (PCDFs), led to the development of what was later referred to as Yusho oil disease. The aim of this study was to investigate the association of maternal PCB and dioxin exposure with adverse pregnancy outcomes in Yusho women. In 2004, we interviewed 214 Yusho women (512 pregnancies) about their pregnancy outcomes over the past 36 years. Pregnancy outcomes included induced abortion, spontaneous abortion, preterm delivery, and pregnancy loss. In pregnancy years 1968–1977 (within the first 10 years after exposure), the proportions of induced abortion [odds ratio adjusted for age at delivery (ORadj) = 5.93; 95% confidence interval (CI), 2.21–15.91; two-tailed p < 0.001) and preterm delivery (ORadj = 5.70; 95% CI, 1.17–27.79; p = 0.03) were significantly increased compared with the proportions in pregnancy years 1958–1967 (10 years before the incident). Spontaneous abortion (ORadj = 2.09; 95% CI, 0.84–5.18), and pregnancy loss (ORadj = 2.11; 95% CI, 0.92–4.87) were more frequent (OR = 2.18; 95% CI, 1.02–4.66), but these were not significant (p = 0.11 and p = 0.08, respectively) in pregnancy years 1968–1977. We found no significant increases in the proportions of these adverse pregnancy outcomes in pregnancies occurring during 1978–1987 or 1988–2003 compared with those in pregnancies before 1968. High levels of PCB/PCDF exposure had some adverse effects on pregnancy outcome in Yusho women.
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DOI：
10.1080/009841099157331
发表时间：
1999-10-15
影响因子：
2.6
作者：
Gladen, BC;Schecter, AJ;Little, RE
通讯作者：
Little, RE
影响因子：
10.4
作者：
MCNULTY, WP
通讯作者：
MCNULTY, WP
影响因子：
8.8
作者：
Ikeda, M
通讯作者：
Ikeda, M
DOI：
10.1016/s0015-6264(76)80251-9
发表时间：
1976-01-01
期刊：
FOOD AND COSMETICS TOXICOLOGY
影响因子：
--
作者：
BARSOTTI, DA;MARLAR, RJ;ALLEN, JR
通讯作者：
ALLEN, JR
影响因子：
10.4
作者：
KUNITA, N;HORI, S;IKEGAMI, N
通讯作者：
IKEGAMI, N