Executive Functions and Impulsivity as Transdiagnostic Correlates of Psychopathology in Childhood: A Behavioral Genetic Analysis.
Executive Functions and Impulsivity as Transdiagnostic Correlates of Psychopathology in Childhood: A Behavioral Genetic Analysis.
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DOI：
10.3389/fnhum.2022.863235
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发表时间：
2022
影响因子：
2.9
通讯作者：
Friedman, Naomi P.
中科院分区：
文献类型：
--
作者：
Freis, Samantha M.;Morrison, Claire L.;Smolker, Harry R.;Banich, Marie T.;Kaiser, Roselinde H.;Hewitt, John K.;Friedman, Naomi P.
执行功能（EFs）和冲动性是自我调节的两个维度，都与精神病理学有关。然而，冲动性的自我报告测量和实验室EF任务通常显示出很小的相关性，现有的研究表明，冲动性和EF可能利用了自我调节的不同方面，这些方面在统计上独立地预测了成年后的精神病理。然而，儿童期与成年期相比，ef、冲动和精神病理之间的关系可能有所不同。在这里，我们研究了这些模式是否适用于青少年大脑和认知发展（ABCD）样本的基线评估，该样本是一个超过11,000名9-10岁儿童（包括749对双胞胎）的全国样本。我们研究了ef的不同成分和冲动性的多个方面的潜在变量之间的表型和遗传关系。此外，我们还评估了ef和冲动性与来自父母报告的精神病理学的综合测量和潜在变量之间的关系。电磁场与冲动性的相关性较弱，且强度随冲动性的不同而不同，强调了它们的可分离性。我们没有发现ef和冲动性之间有显著的遗传和环境相关性。此外，在控制它们之间的小关系后，从统计上看，ef和冲动性的某些方面都预测了外化因素、注意力问题和社会问题，双胞胎分析表明这些关系是遗传的。这些发现表明，ef和冲动性代表了自我调节的表型和基因可分离的方面，它们都是儿童精神病理的跨诊断相关因素。
Executive functions (EFs) and impulsivity are dimensions of self-regulation that are both related to psychopathology. However, self-report measures of impulsivity and laboratory EF tasks typically display small correlations, and existing research indicates that impulsivity and EFs may tap separate aspects of self-regulation that independently statistically predict psychopathology in adulthood. However, relationships between EFs, impulsivity, and psychopathology may be different in childhood compared to adulthood. Here, we examine whether these patterns hold in the baseline assessment of the Adolescent Brain and Cognitive Development (ABCD) sample, a national sample of over 11,000 children (including 749 twin pairs) ages 9–10 years. We examine the phenotypic and genetic relationships among latent variables for different components of EFs and multiple facets of impulsivity. Additionally, we assess how EFs and impulsivity relate to composite measures and latent variables of psychopathology derived from parent report. EFs were weakly correlated with impulsivity, and the strength varied by impulsivity facet, emphasizing their separability. We did not identify significant genetic and environmental correlations between EFs and impulsivity. Moreover, controlling for their small relationships with each other, both EFs and some facets of impulsivity statistically predicted an Externalizing factor, attention problems, and social problems, and twin analyses suggested these relationships were genetic in origin. These findings indicate that EFs and impulsivity represent phenotypically and genetically separable aspects of self-regulation that are both transdiagnostic correlates of psychopathology in childhood.
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影响因子：
2.6
作者：
Donati G;Meaburn E;Dumontheil I
通讯作者：
Dumontheil I
DOI：
10.1177/2167702619898814
发表时间：
2020-05-01
期刊：
Clinical psychological science : a journal of the Association for Psychological Science
影响因子：
--
作者：
Friedman NP;Hatoum AS;Gustavson DE;Corley RP;Hewitt JK;Young SE
通讯作者：
Young SE
影响因子：
3.4
作者：
Bickel, Warren K.;Jarmolowicz, David P.;Mueller, E. Terry;Gatchalian, Kirstin M.;McClure, Samuel M.
通讯作者：
McClure, Samuel M.
影响因子：
3.7
作者：
Freis SM;Morrison CL;Lessem JM;Hewitt JK;Friedman NP
通讯作者：
Friedman NP
影响因子：
1.5
作者：
Barkley, Russell A.;Fischer, Mariellen
通讯作者：
Fischer, Mariellen