Executive Functions and Impulsivity are Genetically Distinct and Independently Predict Psychopathology: Results from Two Adult Twin Studies.
Executive Functions and Impulsivity are Genetically Distinct and Independently Predict Psychopathology: Results from Two Adult Twin Studies.
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DOI：
10.1177/2167702619898814
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发表时间：
2020-05-01
期刊：
影响因子：
--
通讯作者：
Young SE
中科院分区：
文献类型：
--
作者：
Friedman NP;Hatoum AS;Gustavson DE;Corley RP;Hewitt JK;Young SE
实验室执行功能(EF)结构，如反应抑制，通常在概念上与冲动的自我报告测量联系在一起，但它们的经验相关性很低。在两个双胞胎研究中(NS=749和761个有EF数据的个体)，我们考察了三个EF潜在变量(一个共同的EF因素预测反应抑制、工作记忆更新和心理定势转移任务，以及更新和转移特定因素)与五个冲动维度(消极和积极的紧迫感、缺乏预见性和毅力以及感觉寻求)的表型和遗传重叠。在两个样本中，冲动性维度仅与共同EF有适度的表型相关(rS=−.20-.11)和遗传相关(ras=−.44-.04)。在两个样本中，共同EF和多个冲动维度，特别是负性紧迫感，独立地预测外化性精神病，而多个冲动维度，但不是共同EF，预测内化性精神病。这些结果表明，EFS和自我报告的冲动利用了控制的不同方面，这两个方面都与精神病理学有关。
Laboratory executive function (EF) constructs, such as response inhibition, are often conceptually linked with self-report measures of impulsivity, yet their empirical correlations are low. We examined, in two twin studies (Ns=749 and 761 individuals with EF data), the phenotypic and genetic overlap of three EF latent variables (a Common EF factor predicting response inhibition, working memory updating, and mental set shifting tasks, and Updating- and Shifting-specific factors) with five impulsivity dimensions (negative and positive urgency, lack of premeditation and perseverance, and sensation seeking). In both samples, impulsivity dimensions only modestly correlated phenotypically (rs= −.20–.11) and genetically (rAs= −.44–.04) with Common EF. In both samples, Common EF and multiple impulsivity dimensions, particularly negative urgency, independently predicted Externalizing psychopathology, and multiple impulsivity dimensions, but not Common EF, predicted Internalizing psychopathology. These results suggest that EFs and self-reported impulsivity tap different aspects of control that are both relevant for psychopathology.
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