Development of brain-wide connectivity architecture in awake rats.
Development of brain-wide connectivity architecture in awake rats.
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DOI：
10.1016/j.neuroimage.2018.05.009
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发表时间：
2018-08-01
期刊：
影响因子：
5.7
通讯作者：
Zhang N
中科院分区：
文献类型：
--
作者：
Ma Z;Ma Y;Zhang N
儿童期和青春期都是关键的发育时期，大脑经历复杂的神经生理学变化以及这些时期神经精神疾病的高发生率就证明了这一点。尽管在阐明个体神经回路的发育轨迹方面取得了实质性进展，但我们对动物全脑连接结构的发育变化的了解仍然很少。为了填补这一空白，我们纵向采集了清醒大鼠从幼年到成年的五个发育阶段的 rsfMRI 数据。我们发现大脑回路的成熟时间线是异质的并且是特定于系统的。在发育过程中，皮质下回路的功能连接（FC）往往会减少，但皮质回路会增加。此外，发育中的大脑表现出半球功能特化，这可以通过同伦区域之间的半球间 FC 减少以及两个半球之间区域间 FC 模式的较低相似性来证明。最后，我们表明全脑网络发展的特点是减少集群（即本地通信）但增加集成（远程通信）。总而言之，本研究系统地描述了清醒大鼠从幼年到成年的全脑连接结构的发展。它还可以作为理解大脑发育相关疾病动物模型中回路和网络水平变化的关键参考点。此外，清醒啮齿类动物大脑发育过程中的 FC 数据具有很高的转化价值，可以为比较神经解剖学提供启示。
Childhood and adolescence are both critical developmental periods, evidenced by complex neurophysiological changes the brain undergoes and high occurrence rates of neuropsychiatric disorders during these periods. Despite substantial progress in elucidating the developmental trajectories of individual neural circuits, our knowledge of developmental changes of whole-brain connectivity architecture in animals is sparse. To fill this gap, here we longitudinally acquired rsfMRI data in awake rats during five developmental stages from juvenile to adulthood. We found that the maturation timelines of brain circuits were heterogeneous and system specific. Functional connectivity (FC) tended to decrease in subcortical circuits, but increase in cortical circuits during development. In addition, the developing brain exhibited hemispheric functional specialization, evidenced by reduced inter-hemispheric FC between homotopic regions, and lower similarity of region-to-region FC patterns between the two hemispheres. Finally, we showed that whole-brain network development was characterized by reduced clustering (i.e. local communication) but increased integration (distant communication). Taken together, the present study has systematically characterized the development of brain-wide connectivity architecture from juvenile to adulthood in awake rats. It also serves as a critical reference point for understanding circuit- and network-level changes in animal models of brain development-related disorders. Furthermore, FC data during brain development in awake rodents contain high translational value and can shed light onto comparative neuroanatomy.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
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通讯作者：
Thompson, PM
影响因子：
5.7
作者：
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影响因子：
5.7
作者：
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8.2
作者：
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通讯作者：
Andersen, SL
影响因子：
3.7
作者：
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通讯作者：
Lainhart, Janet E.