Shape abnormalities of subcortical and ventricular structures in mild cognitive impairment and Alzheimer's disease: detecting, quantifying, and predicting.
Shape abnormalities of subcortical and ventricular structures in mild cognitive impairment and Alzheimer's disease: detecting, quantifying, and predicting.
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DOI：
10.1002/hbm.22431
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发表时间：
2014-08
影响因子：
4.8
通讯作者：
Miller, Michael I.
中科院分区：
文献类型：
--
作者：
Tang, Xiaoying;Holland, Dominic;Dale, Anders M.;Younes, Laurent;Miller, Michael I.
关键词：
本文评估了使用形状信息检测和量化轻度认知障碍（MCI）和阿尔茨海默病（AD）患者皮质下和心室结构变化的可行性。我们首先证明了MCI和AD与健康对照（HC）相比的结构形状异常。然后，我们根据纵向临床信息将MCI参与者分为两组：(1)保持稳定的MCI患者；(2) MCI患者随着时间的推移转化为AD。我们在754次磁共振扫描中重点研究了7个结构（杏仁核、海马、丘脑、尾状核、壳核、苍白球和侧脑室）（210次HC， 369次MCI，其中151次随时间转换为AD， 175次AD）。在高场0.8 mm各向同性7.0T扫描的基础上，进一步对海马和杏仁核进行亚段分割，以进行更精细的探查。对于MCI和AD，检测到明显的心室扩张，我们发现这些患者在CA1发生最强烈的海马萎缩，在基底外侧复合体发生最强烈的杏仁核萎缩。MCI和AD患者基底神经节结构也出现轻度萎缩。与MCI保持稳定者相比，MCI转换者的杏仁核和海马体萎缩更强，脑室扩张更大。此外，我们对每个结构的线性形状空间进行了主成分分析。随后对海马体、杏仁核和脑室的主成分值进行线性判别分析，对88%的HC受试者和86%的AD受试者进行了正确的分类。
This article assesses the feasibility of using shape information to detect and quantify the subcortical and ventricular structural changes in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients. We first demonstrate structural shape abnormalities in MCI and AD as compared with healthy controls (HC). Exploring the development to AD, we then divide the MCI participants into two subgroups based on longitudinal clinical information: (1) MCI patients who remained stable; (2) MCI patients who converted to AD over time. We focus on seven structures (amygdala, hippocampus, thalamus, caudate, putamen, globus pallidus, and lateral ventricles) in 754 MR scans (210 HC, 369 MCI of which 151 converted to AD over time, and 175 AD). The hippocampus and amygdala were further subsegmented based on high field 0.8 mm isotropic 7.0T scans for finer exploration. For MCI and AD, prominent ventricular expansions were detected and we found that these patients had strongest hippocampal atrophy occurring at CA1 and strongest amygdala atrophy at the basolateral complex. Mild atrophy in basal ganglia structures was also detected in MCI and AD. Stronger atrophy in the amygdala and hippocampus, and greater expansion in ventricles was observed in MCI converters, relative to those MCI who remained stable. Furthermore, we performed principal component analysis on a linear shape space of each structure. A subsequent linear discriminant analysis on the principal component values of hippocampus, amygdala, and ventricle leads to correct classification of 88% HC subjects and 86% AD subjects.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
5.7
作者：
Cho Y;Seong JK;Jeong Y;Shin SY;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
DOI：
10.1093/brain/awp123
发表时间：
2009-08
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Desikan RS;Cabral HJ;Hess CP;Dillon WP;Glastonbury CM;Weiner MW;Schmansky NJ;Greve DN;Salat DH;Buckner RL;Fischl B;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
9.9
作者：
Csernansky, JG;Wang, L;Miller, MI
通讯作者：
Miller, MI
影响因子：
4.2
作者：
Dickerson, BC;Goncharova, I;deToledo-Morrell, L
通讯作者：
deToledo-Morrell, L