Bryostatins: biological context and biotechnological prospects.
Bryostatins: biological context and biotechnological prospects.
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DOI：
10.1016/j.copbio.2010.09.018
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发表时间：
2010-12
影响因子：
7.7
通讯作者：
Haygood, Margo G.
中科院分区：
文献类型：
--
作者：
Trindade-Silva, Amaro E.;Lim-Fong, Grace E.;Sharp, Koty H.;Haygood, Margo G.
苔藓抑素是一类蛋白激酶C调节剂家族，在生物医学领域具有潜在的应用价值。在一种小型海洋无脊椎动物中发现的数量微乎其微，缺乏供应阻碍了它们的发展。近年来，苔藓抑素在中枢神经系统中具有很强的生物活性，未培养的海洋细菌共生体被证明是苔藓抑素的天然来源，苔藓抑素生物合成基因已被鉴定和表征，具有良好生物活性的苔藓抑素类似物已被开发和测试。苔藓抑素在生物医学和生物技术应用中的发展面临的挑战包括细菌共生体的培养和苔藓抑素生物合成基因的异源表达。对苔藓抑素的生物学和共生起源的持续探索为发现另外的苔藓抑素和苔藓抑素的新功能提供了有希望的机会。
Bryostatins are a family of protein kinase C modulators that have potential applications in biomedicine. Found in miniscule quantities in a small marine invertebrate, lack of supply has hampered their development. In recent years, bryostatins have been shown to have potent bioactivity in the central nervous system, an uncultivated marine bacterial symbiont has been shown to be the likely natural source of the bryostatins, the bryostatin biosynthetic genes have been identified and characterized, and bryostatin analogues with promising biological activity have been developed and tested. Challenges in development of bryostatins for biomedical and biotechnological application include the cultivation of the bacterial symbiont and heterologous expression of bryostatin biosynthesis genes. Continued exploration of the biology and the symbiotic origin of the bryostatins presents promising opportunities for discovery of additional bryostatins, and new functions for bryostatins.
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DOI：
10.1016/s1389-0344(03)00075-3
发表时间：
2003-07-01
期刊：
BIOMOLECULAR ENGINEERING
影响因子：
--
作者：
Mendola, D
通讯作者：
Mendola, D
影响因子：
1.6
作者：
Davidson, SK;Haygood, MG
通讯作者：
Haygood, MG
影响因子：
2.2
作者：
Abadi, Giso;Manning, Thomas J.;Potter, Thomas
通讯作者：
Potter, Thomas
影响因子：
2.4
作者：
Lindquist, N
通讯作者：
Lindquist, N
影响因子：
2.5
作者：
Lopanik, Nicole B.;Targett, Nancy M.;Lindquist, Niels
通讯作者：
Lindquist, Niels