Impulsive choice predicts anxiety-like behavior, but not alcohol or sucrose consumption, in male Long-Evans rats.
Impulsive choice predicts anxiety-like behavior, but not alcohol or sucrose consumption, in male Long-Evans rats.
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DOI：
10.1111/acer.12713
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Madden GJ
中科院分区：
文献类型：
--
作者：
Stein JS;Renda CR;Barker SM;Liston KJ;Shahan TA;Madden GJ
先前的人类研究表明，冲动选择（即，偏好较小的、即时的奖励，而不是较大的、延迟的奖励）和酒精使用障碍。然而，非人类文献中的不同发现揭示了啮齿动物冲动选择和饮酒之间相对模糊的关系。此外，很少有啮齿动物研究调查冲动选择与饮酒的常见协变量之间的潜在关系（例如，对甜味物质的渴望或焦虑样行为）。92只雄性Long-Evans大鼠完成了一项冲动选择任务。从这个较大的样本中，保留极高和极低脉冲组（每组n = 30）进行进一步测试。在单独的测试中，随后的旷场行为和口服酒精（12%wt/vol）和等热量蔗糖的消耗进行了检查。然后再次测试冲动选择，以检查行为是否在实验过程中保持稳定。冲动性选择与酒精或蔗糖消费之间没有显着关系。然而，冲动的选择预测更大的焦虑样行为（避免中心领域，排便）在开放领域的测试。反过来，更大的焦虑预示着更低的酒精和蔗糖消费。最后，在整个实验过程中，选择大体上保持稳定，尽管冲动大鼠在重新测试中倾向于不那么冲动的选择。尽管冲动选择和饮酒似乎与焦虑样行为存在一些差异，但目前的数据并没有支持Long-Evans大鼠冲动选择和饮酒之间的关系。再加上之前报告中的混合啮齿动物数据，这些发现减弱了冲动选择和酒精使用障碍之间人类关系的跨物种比较。
Prior human research indicates robust, positive relations between impulsive choice (i.e., preference for smaller, immediate over larger, delayed rewards) and alcohol-use disorders. However, varied findings in the nonhuman literature reveal a relatively ambiguous relation between impulsive choice and alcohol consumption in rodents. Moreover, few rodent studies have investigated potential relations between impulsive choice and common covariates of alcohol consumption (e.g., avidity for sweet substances or anxiety-like behavior). Ninety-two male Long-Evans rats completed an impulsive-choice task. From this larger sample, extreme high- and low-impulsive groups (n = 30 each) were retained for further testing. In separate tests, subsequent open-field behavior and consumption of oral alcohol (12% wt/vol) and isocaloric sucrose were examined. Impulsive choice was then retested to examine whether behavior remained stable over the course of the experiment. No significant relations emerged between impulsive choice and either alcohol or sucrose consumption. However, impulsive choice predicted greater anxiety-like behavior (avoidance of the center field, defecation) in the open-field test. In turn, greater anxiety predicted lower alcohol and sucrose consumption. Finally, choice remained generally stable across the experiment, although impulsive rats tended toward less impulsive choice in the retest. Although impulsive choice and alcohol consumption appear to share some variance with anxiety-like behavior, the present data offer no support for a relation between impulsive choice and alcohol consumption in Long-Evans rats. Together with mixed rodent data from prior reports, these findings attenuate cross-species comparisons to human relations between impulsive choice and alcohol-use disorders.
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影响因子：
3.4
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