Assessment of PSIM (Prostatic Systemic Inflammatory Markers) Score in Predicting Pathologic Features at Robotic Radical Prostatectomy in Patients with Low-Risk Prostate Cancer Who Met the Inclusion Criteria for Active Surveillance.
Assessment of PSIM (Prostatic Systemic Inflammatory Markers) Score in Predicting Pathologic Features at Robotic Radical Prostatectomy in Patients with Low-Risk Prostate Cancer Who Met the Inclusion Criteria for Active Surveillance.
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DOI：
10.3390/diagnostics11020355
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发表时间：
2021-02-20
期刊：
影响因子：
--
通讯作者：
de Cobelli O
中科院分区：
文献类型：
--
作者：
Ferro M;Musi G;Matei DV;Mistretta AF;Luzzago S;Cozzi G;Bianchi R;Di Trapani E;Cioffi A;Lucarelli G;Busetto GM;Del Giudice F;Russo GI;Di Mauro M;Porreca A;Renne G;Catellani M;Bottero D;Brescia A;Cordima G;de Cobelli O
Background: circulating levels of lymphocytes, platelets and neutrophils have been identified as factors related to unfavorable clinical outcome for many solid tumors. The aim of this cohort study is to evaluate and validate the use of the Prostatic Systemic Inflammatory Markers (PSIM) score in predicting and improving the detection of clinically significant prostate cancer (csPCa) in men undergoing robotic radical prostatectomy for low-risk prostate cancer who met the inclusion criteria for active surveillance. Methods: we reviewed the medical records of 260 patients who fulfilled the inclusion criteria for active surveillance. We performed a head-to-head comparison between the histological findings of specimens after radical prostatectomy (RP) and prostate biopsies. The PSIM score was calculated on the basis of positivity according to cutoffs (neutrophil-to-lymphocyte ratio (NLR) 2.0, platelets-to-lymphocyte ratio (PLR) 118 and monocyte-to-lymphocyte-ratio (MLR) 5.0), with 1 point assigned for each value exceeding the specified threshold and then summed, yielding a final score ranging from 0 to 3. Results: median NLR was 2.07, median PLR was 114.83, median MLR was 3.69. Conclusion: we found a significantly increase in the rate of pathological International Society of Urological Pathology (ISUP) ≥ 2 with the increase of PSIM. At the multivariate logistic regression analysis adjusted for age, prostate specific antigen (PSA), PSA density, prostate volume and PSIM, the latter was found the sole independent prognostic variable influencing probability of adverse pathology.
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影响因子：
1.6
作者：
Ferro, Matteo;Musi, Gennaro;de Cobelli, Ottavio
通讯作者：
de Cobelli, Ottavio
影响因子：
15.3
作者：
Bruinsma, Sophie M.;Roobol, Monique J.;Bangma, Chris H.
通讯作者：
Bangma, Chris H.
使用中性粒细胞与淋巴细胞比例在肺癌患者血清和恶性胸腔积液中使用新评分的预后影响。
影响因子：
3.8
作者：
Lee YS;Nam HS;Lim JH;Kim JS;Moon Y;Cho JH;Ryu JS;Kwak SM;Lee HL
通讯作者：
Lee HL
DOI：
10.1016/j.urolonc.2016.05.013
发表时间：
2016-11-01
影响因子：
2.7
作者：
Mbeutcha, Aurelie;Shariat, Shahrokh F.;Klatte, Tobias
通讯作者：
Klatte, Tobias
DOI：
10.1073/pnas.2234372100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Bakewell, SJ;Nestor, P;Weilbaecher, KN
通讯作者：
Weilbaecher, KN