Persistent effects of obesity: a neuroplasticity hypothesis.
Persistent effects of obesity: a neuroplasticity hypothesis.
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DOI：
10.1111/nyas.13665
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发表时间：
2018-09
影响因子：
5.2
通讯作者：
Kravitz AV
中科院分区：
文献类型：
--
作者：
Matikainen-Ankney BA;Kravitz AV
肥胖流行是美国健康问题的主要原因，增加了心血管、内分泌和精神疾病的风险。虽然许多人通过改变饮食和生活方式来减肥，但保持体重仍然是一个挑战。在这里，我们讨论一个假说，试图解释为什么肥胖是如此持久。物质使用障碍和肥胖症所涉及的回路有很大程度的重叠，这些回路对药物滥用的神经可塑性有很好的记录。我们假设肥胖也与这些回路中的神经可塑性有关，这可能是行为，能量平衡和体重持续变化的基础。在这里，我们讨论如何肥胖相关的动机和体力活动的减少可能植根于这些电路的神经生理学改变。这种可塑性可能会改变人类和动物使用，消耗和储存能量的方式，即使在体重减轻之后。肥胖流行是美国健康问题的主要原因，增加了心血管、内分泌和精神疾病的风险。在这里，我们讨论如何肥胖相关的动机和体力活动的减少可能植根于这些电路的神经生理学改变。这种可塑性可能会改变人类和动物使用，消耗和储存能量的方式，即使在体重减轻之后。
The obesity epidemic is a leading cause of health problems in the United States, increasing the risk of cardiovascular, endocrine, and psychiatric diseases. Though many people lose weight through changes in diet and lifestyle, keeping the weight off remains a challenge. Here, we discuss a hypothesis that seeks to explain why obesity is so persistent. There is a great degree of overlap in the circuits implicated in substance use disorder and obesity, and neural plasticity of these circuits in response to drugs of abuse is well documented. We hypothesize that obesity is also associated with neural plasticity in these circuits, and this may underlie persistent changes in behavior, energy balance, and body weight. Here, we discuss how obesity-associated reductions in motivation and physical activity may be rooted in neurophysiological alterations in these circuits. Such plasticity may alter how humans and animals use, expend, and store energy, even after weight loss. The obesity epidemic is a leading cause of health problems in the United States, increasing the risk of cardiovascular, endocrine, and psychiatric diseases. Here, we discuss how obesity-associated reductions in motivation and physical activity may be rooted in neurophysiological alterations in these circuits. Such plasticity may alter how humans and animals use, expend, and store energy, even after weight loss.
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DOI：
10.1038/oby.2010.88
发表时间：
2010-12
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Bond DS;Jakicic JM;Unick JL;Vithiananthan S;Pohl D;Roye GD;Ryder BA;Sax HC;Wing RR
通讯作者：
Wing RR
影响因子：
3.5
作者：
Beeler JA;Frazier CR;Zhuang X
通讯作者：
Zhuang X
影响因子：
5.7
作者：
Chen, Po See;Yang, Yen Kuang;Lu, Ru Band
通讯作者：
Lu, Ru Band
影响因子：
2.5
作者：
BELLINGER, FP;MADAMBA, SG;SIGGINS, GR
通讯作者：
SIGGINS, GR
影响因子：
2.7
作者：
Camacho, Alberto;Montalvo-Martinez, Larisa;Garza-Ocanas, Lourdes
通讯作者：
Garza-Ocanas, Lourdes