Environmental exposure to metals and children's growth to age 5 years: a prospective cohort study.
Environmental exposure to metals and children's growth to age 5 years: a prospective cohort study.
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DOI：
10.1093/aje/kws437
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发表时间：
2013-06-15
影响因子：
5
通讯作者：
Vahter M
中科院分区：
文献类型：
--
作者：
Gardner RM;Kippler M;Tofail F;Bottai M;Hamadani J;Grandér M;Nermell B;Palm B;Rasmussen KM;Vahter M
在这项前瞻性队列研究中，基于孟加拉国农村地区的1，505对母婴，我们评估了2001-2009年期间，通过母亲和儿童尿液中的浓度评估的早期生活暴露于砷，镉和铅与5岁以下儿童体重和身高之间的关联。使用线性回归分析评估同时和产前暴露，而使用混合效应线性回归评估纵向暴露。发现儿童的体重和身高、年龄调整的z分数、5岁时的生长速度与同时暴露于镉和砷之间存在负相关。在纵向分析中，5岁儿童体重的多变量调整归因差异为-0.33 kg与最低暴露量（≤第5百分位数）的儿童相比，高（≥第95百分位数）砷暴露的儿童体重为-0.60，-0.06），高镉暴露的儿童体重为-0.57 kg（95% CI：-0.88，-0.26）。高砷暴露和高镉暴露的身高多变量调整归因差异分别为-0.50 cm（95% CI：-1.20，0.21）和-1.6 cm（95% CI：-2.4，0.77）。这种联系主要在女孩中很明显。砷和镉对5岁儿童生长的负面影响与女孩和男孩在体重（-0.67公斤，95%可信区间：-0.82，-0.53）和身高（-1.3厘米，95%可信区间：-1.7，-0.89）方面的差异程度相似。
In this prospective cohort study, based on 1,505 mother-infant pairs in rural Bangladesh, we evaluated the associations between early-life exposure to arsenic, cadmium, and lead, assessed via concentrations in maternal and child urine, and children's weights and heights up to age 5 years, during the period 2001–2009. Concurrent and prenatal exposures were evaluated using linear regression analysis, while longitudinal exposure was assessed using mixed-effects linear regression. An inverse association was found between children's weight and height, age-adjusted z scores, and growth velocity at age 5 years and concurrent exposure to cadmium and arsenic. In the longitudinal analysis, multivariable-adjusted attributable differences in children's weight at age 5 years were −0.33 kg (95% confidence interval (CI): −0.60, −0.06) for high (≥95th percentile) arsenic exposure and −0.57 kg (95% CI: −0.88, −0.26) for high cadmium exposure, in comparison with children with the lowest exposure (≤5th percentile). Multivariable-adjusted attributable differences in height were −0.50 cm (95% CI: −1.20, 0.21) for high arsenic exposure and −1.6 cm (95% CI: −2.4, −0.77) for high cadmium exposure. The associations were apparent primarily among girls. The negative effects on children's growth at age 5 years attributable to arsenic and cadmium were of similar magnitude to the difference between girls and boys in terms of weight (−0.67 kg, 95% CI: −0.82, −0.53) and height (−1.3 cm, 95% CI: −1.7, −0.89).
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影响因子：
4.5
作者：
Kippler, Maria;Loennerdal, Bo;Vahter, Marie
通讯作者：
Vahter, Marie
影响因子：
3.5
作者：
Kippler, Maria;Nermell, Barbro;Vahter, Marie
通讯作者：
Vahter, Marie
影响因子：
10.4
作者：
Kippler M;Tofail F;Gardner R;Rahman A;Hamadani JD;Bottai M;Vahter M
通讯作者：
Vahter M
影响因子：
5.1
作者：
Ballew, C;Khan, LK;Gunter, EW
通讯作者：
Gunter, EW
DOI：
10.2471/blt.07.043497
发表时间：
2007-09-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Onis, Mercedes de;Onyango, Adelheid W;Siekmann, Jonathan
通讯作者：
Siekmann, Jonathan