Traditional Chinese medicine for transformation of gastric precancerous lesions to gastric cancer: A critical review.

Traditional Chinese medicine for transformation of gastric precancerous lesions to gastric cancer: A critical review.
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中医药治疗胃癌前病变向胃癌的转化:综述

DOI:
10.4251/wjgo.v15.i1.36
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发表时间:
2023-01-15
影响因子:
3
通讯作者:
Li B
Li B
中科院分区:
医学4区
文献类型:
--
作者:
Zhong YL;Wang PQ;Hao DL;Sui F;Zhang FB;Li B

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胃癌是一种常见的胃肠道肿瘤。胃癌前病变(GPL)是正常胃黏膜向胃癌转变前的最后一个病理阶段。然而,阻止从GPL到GC的转换仍然是一个挑战。中医用于治疗胃病已有上千年的历史。一系列中药方剂和活性化合物在GC和GPL中均显示出治疗作用。本文综述了近年来中药在阻止GPL向GC转化方面的研究进展,重点介绍了抗炎、抗血管生成、增殖和细胞凋亡等方面的研究进展。本文综述可为中医药预防GPL向GC转化提供有意义的参考。
Gastric cancer (GC) is a common gastrointestinal tumor. Gastric precancerous lesions (GPL) are the last pathological stage before normal gastric mucosa transforms into GC. However, preventing the transformation from GPL to GC remains a challenge. Traditional Chinese medicine (TCM) has been used to treat gastric disease for millennia. A series of TCM formulas and active compounds have shown therapeutic effects in both GC and GPL. This article reviews recent progress on the herbal drugs and pharmacological mechanisms of TCM in preventing the transformation from GPL to GC, especially focusing on anti-inflammatory, anti-angiogenesis, proliferation, and apoptosis. This review may provide a meaningful reference for the prevention of the transformation from GPL to GC using TCM.
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