Antibody-recruiting molecules: an emerging paradigm for engaging immune function in treating human disease.
Antibody-recruiting molecules: an emerging paradigm for engaging immune function in treating human disease.
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DOI：
10.1021/cb300119g
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发表时间：
2012-07-20
影响因子：
4
通讯作者：
Spiegel, David A.
中科院分区：
文献类型：
--
作者：
McEnaney, Patrick J.;Parker, Christopher G.;Zhang, Andrew X.;Spiegel, David A.
合成免疫学是开发能够调节和/或操纵免疫功能的合成系统，代表着一个具有多种可能性的新兴研究领域。这一领域的一个重点是创造低分子合成物种，称为抗体募集分子(ARM)，它能够增强抗体与疾病相关细胞或病毒的结合，从而导致它们通过免疫介导的清除。这篇文章从基于小分子的抗体识别调节技术的历史开始，对这一领域的贡献进行了深入的讨论，然后系统地回顾了基于ARM的策略的各种应用。因此，我们描述了能够针对癌症、细菌和病毒病原体的武器，以及由于它们的发展而产生的一些科学发现。这一领域的研究强调了有机化学和免疫生物学之间的许多令人兴奋的可能性，并定位于在未来几年推动基础和临床科学的发展。
Synthetic Immunology, the development of synthetic systems capable of modulating and/or manipulating immunological functions, represents an emerging field of research with manifold possibilities. One focus of this area has been to create low molecular-weight synthetic species, called antibody-recruiting molecules (ARMs), which are capable of enhancing antibody binding to disease-relevant cells or viruses, thus leading to their immune-mediated clearance. This article provides a thorough discussion of contributions in this area, beginning with the history of small-molecule-based technologies for modulating antibody recognition, followed by a systematic review of the various applications of ARM-based strategies. Thus, we describe ARMs capable of targeting cancer, bacteria, and viral pathogens, along with some of the scientific discoveries that have resulted from their development. Research in this area underscores the many exciting possibilities at the interface of organic chemistry and immunobiology, and is positioned to advance both basic and clinical science in the years to come.
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